125048-93-3

Upstream product

• 125024-19-3 2,2-Dimethyl-propionic acid (E)-(2S,3S)-6-benzenesulfinyl-6-[(2S,4S,6R,8R,9S)-8-((S)-sec-butyl)-4-(4-methoxy-benzyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-2,4-dimethyl-3-(2-trimethylsilanyl-ethoxymethoxy)-hex-4-enyl ester 
• 6742-53-6 (E)-ethyl 4-oxo-2-pentenoate 
• 1565-80-6 (2S)-2-methyl-1-butanol 
• 1730-97-8 (S)-2-methylbutyraldehyde 
• 125024-14-8 (2S,3S)-3-<<2-(trimethylsilyl)ethoxy>methoxy>-2-methyl-4-oxopentyl pivalate 
• 82917-20-2 (3S,4R,5S)-3,5-Dimethyl-1-hepten-4-ol 
• 824-94-2 p-methoxybenzyl chloride 
• 119650-00-9 [(2S,4S,6R,8R,9S)-8-((S)-sec-Butyl)-4-(4-methoxy-benzyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-methanol 
• 125024-15-9 (2S,4S,6R,8R,9S)-8-((S)-sec-Butyl)-4-(4-methoxy-benzyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-ene-2-carbaldehyde 
• 163452-37-7 (2S,4R)-1,2,6-trihydroxy-4-<(p-methoxybenzyl)oxy>hexane 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 125024-18-2 2,2-Dimethyl-propionic acid (E)-(2S,3S)-6-[(2S,4S,6S,8R,9S)-8-((S)-sec-butyl)-4-(4-methoxy-benzyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-4-hydroxy-2,4-dimethyl-3-(2-trimethylsilanyl-ethoxymethoxy)-hex-5-enyl ester 
• 125024-16-0 2,2-Dimethyl-propionic acid (2S,3S)-6-[(2S,4S,6R,8R,9S)-8-((S)-sec-butyl)-4-(4-methoxy-benzyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-6-hydroxy-2-methyl-4-oxo-3-(2-trimethylsilanyl-ethoxymethoxy)-hexyl ester 
• 125024-17-1 2,2-Dimethyl-propionic acid (E)-(2S,3S)-6-[(2S,4S,6S,8R,9S)-8-((S)-sec-butyl)-4-(4-methoxy-benzyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-2-methyl-4-oxo-3-(2-trimethylsilanyl-ethoxymethoxy)-hex-5-enyl ester 

Downstream Products

• 125024-20-6 2,2-Dimethyl-propionic acid (E)-(2S,3S)-6-benzenesulfonyl-6-[(2S,4S,6R,8R,9S)-8-((S)-sec-butyl)-4-hydroxy-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-2,4-dimethyl-3-(2-trimethylsilanyl-ethoxymethoxy)-hex-4-enyl ester 
• 125024-22-8 (E)-(2S,3S)-6-Benzenesulfonyl-6-[(2S,4S,6R,8R,9S)-8-((S)-sec-butyl)-4-(tert-butyl-dimethyl-silanyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-2,4-dimethyl-3-(2-trimethylsilanyl-ethoxymethoxy)-hex-4-en-1-ol 
• 125024-28-4 (2R,3S,6S,8R,10S)-8-[(2E,6E)-(4S,5S)-8-Benzenesulfonyl-3,5-dimethyl-4-(2-trimethylsilanyl-ethoxymethoxy)-octa-2,6-dienyl]-2-((S)-sec-butyl)-10-(tert-butyl-dimethyl-silanyloxy)-3-methyl-1,7-dioxa-spiro[5.5]undec-4-ene 
• 125024-21-7 2,2-Dimethyl-propionic acid (E)-(2S,3S)-6-benzenesulfonyl-6-[(2S,4S,6R,8R,9S)-8-((S)-sec-butyl)-4-(tert-butyl-dimethyl-silanyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-2,4-dimethyl-3-(2-trimethylsilanyl-ethoxymethoxy)-hex-4-enyl ester 
• 125048-94-4 C₆₄H₁₁₀O₁₃SSi₄ 
• 125024-35-3 C₆₅H₁₁₄O₁₄SSi₄ 

Relevant academic research and scientific papers

Total synthesis of the antiparasitic agent avermectin B1a

The synthesis of avermectin B1a has been completed by a route that assembles the aglycon from three subunits consisting of the hexahydrobenzofuran moiety (A), the spiroketal segment (B), and the acyclic portion (C) comprising C9-C15. Connection is made in a B + C → (B -C) + A sequence, and the synthesis is concluded by attachment to the aglycon of the L-oleandrosyl-L-oleandrose disaccharide via the pyridylthio glycoside.