119662-87-2

Upstream product

• 119649-95-5 (1S,3S,5R)-3-(4-Methoxy-benzyloxy)-6,8-dioxa-bicyclo[3.2.1]octane 
• 1565-80-6 (2S)-2-methyl-1-butanol 
• 181488-63-1 1,6-anhydro-β-D-glucopyranose 
• 163452-37-7 (2S,4R)-1,2,6-trihydroxy-4-<(p-methoxybenzyl)oxy>hexane 
• 824-94-2 p-methoxybenzyl chloride 
• 116315-39-0 (3S,4R,5S)-1,1-dibromo-4-<(tert-butyldimethylsilyl)oxy>-3,5-dimethyl-1-heptene 
• 105989-27-3 (2S,3R,4S)-3-<(tert-butyldimethylsilyl)oxy>-2,4-dimethylhexanal 
• 105989-30-8 (3S,4R,5s)-4-<(tert-butyldimethylsilyl)oxy>-3,5-dimethyl-1-heptyne 
• 119662-86-1 (2R,7S,8R,9S)-8-(tert-Butyl-dimethyl-silanyloxy)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxy)-7,9-dimethyl-undec-5-yn-4-ol 
• 119649-97-7 (R)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-butan-1-ol 
• 119649-98-8 (S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-butyraldehyde 
• 119650-01-0 (3S,4R,5S)-4-<(tert-butyldimethylsilyl)oxy>-3,5-dimethyl-1-heptene 
• 1730-97-8 (S)-2-methylbutyraldehyde 
• 67-56-1 methanol 

Downstream Products

• 119662-88-3 (3S,4R,5S)-1-[(4S,6S)-6-Hydroxymethyl-2-methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-3,5-dimethyl-hept-1-yn-4-ol 
• 125024-17-1 2,2-Dimethyl-propionic acid (E)-(2S,3S)-6-[(2S,4S,6S,8R,9S)-8-((S)-sec-butyl)-4-(4-methoxy-benzyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-2-methyl-4-oxo-3-(2-trimethylsilanyl-ethoxymethoxy)-hex-5-enyl ester 
• 125024-20-6 2,2-Dimethyl-propionic acid (E)-(2S,3S)-6-benzenesulfonyl-6-[(2S,4S,6R,8R,9S)-8-((S)-sec-butyl)-4-hydroxy-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-2,4-dimethyl-3-(2-trimethylsilanyl-ethoxymethoxy)-hex-4-enyl ester 
• 125024-22-8 (E)-(2S,3S)-6-Benzenesulfonyl-6-[(2S,4S,6R,8R,9S)-8-((S)-sec-butyl)-4-(tert-butyl-dimethyl-silanyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-2,4-dimethyl-3-(2-trimethylsilanyl-ethoxymethoxy)-hex-4-en-1-ol 
• 125024-16-0 2,2-Dimethyl-propionic acid (2S,3S)-6-[(2S,4S,6R,8R,9S)-8-((S)-sec-butyl)-4-(4-methoxy-benzyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-6-hydroxy-2-methyl-4-oxo-3-(2-trimethylsilanyl-ethoxymethoxy)-hexyl ester 
• 125024-28-4 (2R,3S,6S,8R,10S)-8-[(2E,6E)-(4S,5S)-8-Benzenesulfonyl-3,5-dimethyl-4-(2-trimethylsilanyl-ethoxymethoxy)-octa-2,6-dienyl]-2-((S)-sec-butyl)-10-(tert-butyl-dimethyl-silanyloxy)-3-methyl-1,7-dioxa-spiro[5.5]undec-4-ene 
• 125024-18-2 2,2-Dimethyl-propionic acid (E)-(2S,3S)-6-[(2S,4S,6S,8R,9S)-8-((S)-sec-butyl)-4-(4-methoxy-benzyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-4-hydroxy-2,4-dimethyl-3-(2-trimethylsilanyl-ethoxymethoxy)-hex-5-enyl ester 
• 125024-19-3 2,2-Dimethyl-propionic acid (E)-(2S,3S)-6-benzenesulfinyl-6-[(2S,4S,6R,8R,9S)-8-((S)-sec-butyl)-4-(4-methoxy-benzyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-2,4-dimethyl-3-(2-trimethylsilanyl-ethoxymethoxy)-hex-4-enyl ester 
• 125024-21-7 2,2-Dimethyl-propionic acid (E)-(2S,3S)-6-benzenesulfonyl-6-[(2S,4S,6R,8R,9S)-8-((S)-sec-butyl)-4-(tert-butyl-dimethyl-silanyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-2,4-dimethyl-3-(2-trimethylsilanyl-ethoxymethoxy)-hex-4-enyl ester 
• 125048-93-3 2,2-Dimethyl-propionic acid (E)-(2S,3S)-6-benzenesulfonyl-6-[(2S,4S,6R,8R,9S)-8-((S)-sec-butyl)-4-(4-methoxy-benzyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-2,4-dimethyl-3-(2-trimethylsilanyl-ethoxymethoxy)-hex-4-enyl ester 
• 119662-89-4 (Z)-(3S,4R,5S)-1-[(4S,6S)-6-Hydroxymethyl-2-methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-3,5-dimethyl-hept-1-en-4-ol 
• 119650-00-9 [(2S,4S,6R,9S)-8-((S)-sec-Butyl)-4-(4-methoxy-benzyloxy)-9-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl]-methanol 

Relevant academic research and scientific papers

Total synthesis of the antiparasitic agent avermectin B1a

The synthesis of avermectin B1a has been completed by a route that assembles the aglycon from three subunits consisting of the hexahydrobenzofuran moiety (A), the spiroketal segment (B), and the acyclic portion (C) comprising C9-C15. Connection is made in a B + C → (B -C) + A sequence, and the synthesis is concluded by attachment to the aglycon of the L-oleandrosyl-L-oleandrose disaccharide via the pyridylthio glycoside.