125056-67-9 Usage
Explanation
Different sources of media describe the Explanation of 125056-67-9 differently. You can refer to the following data:
1. The molecular formula represents the number of atoms of each element present in a molecule of the compound.
2. Pyrimidine derivative
2. It is a compound derived from the base pyrimidine, which is a heterocyclic aromatic organic compound.
3. A sulfanyl group (-SH) is a functional group consisting of a sulfur atom bonded to a hydrogen atom, which is attached to the 6th position of the pyrimidine ring.
4. A nitrophenyl group is a phenyl ring (C6H5) with a nitro group (-NO2) attached to it, which is connected to the 3rd position of the pyrimidine ring.
5. Potential medicinal properties
5. The compound may have therapeutic or pharmaceutical applications, making it a candidate for drug development.
6. Proper handling required
6. Due to its potential adverse effects on human health, it is crucial to handle this chemical with care, following safety protocols and guidelines.
7. The numbers 1H and 3H refer to the hydrogen atoms present in the molecule, with 1 hydrogen atom in the 2nd position and 3 hydrogen atoms in the 4th position of the pyrimidine ring.
8. 2-hydroxyethoxymethyl group
8. This group is attached to the 1st position of the pyrimidine ring and consists of an ethoxy (-OCH2CH3) group with a hydroxyl (-OH) group attached to the carbon next to the oxygen.
9. A methyl group (-CH3) is a single carbon atom bonded to three hydrogen atoms, which is attached to the 5th position of the pyrimidine ring.
10. Dione functional group
10. The term "dione" refers to the presence of two carbonyl groups (C=O) in the molecule, which are typically found in the 2nd and 4th positions of the pyrimidine ring.
Sulfanyl group
attached to the 6th position
Nitrophenyl group
attached to the 3rd position
1H, 3H
Indicates the presence of hydrogen atoms in the molecule
Methyl group
attached to the 5th position
Check Digit Verification of cas no
The CAS Registry Mumber 125056-67-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,0,5 and 6 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 125056-67:
(8*1)+(7*2)+(6*5)+(5*0)+(4*5)+(3*6)+(2*6)+(1*7)=109
109 % 10 = 9
So 125056-67-9 is a valid CAS Registry Number.
125056-67-9Relevant articles and documents
Structure-Activity Relationships of 1--6-(phenylthio)thymine Analogues: Effect of Substitutions at the C-6 Phenyl Ring and at the C-5 Position on Anti-HIV-1 Activity
Tanaka, Hiromichi,Takashima, Hideaki,Ubasawa, Masaru,Sekiya, Kouichi,Nitta, Iasei,et al.
, p. 337 - 345 (2007/10/02)
The effect of substitution on the pyrimidine moiety of 1--6-(phenylthio)thymine (HEPT) and 1--6-(phenylthio)-2-thiothymine (HEPT-S) on anti-HIV-1 activity was investigated by synthesizing a series of 5-methyl-6-(arylthio) and 5-substituted-6-(phenylthio) derivatives.Preparation of the 5-methyl-6-(arylthio) derivatives was carried out based on either LDA lithiation of 1-methyl>thymine (3) and 1-methyl>-2-thiothymine (4) followed by reaction with diaryl disulfides or an addition-elimination reaction of 1-methyl>-6-(phenylsulfinyl)thymine (31) with aromatic thiols.Preparation of the 5-substituted-6-(phenylthio) derivatives was carried out based on either C-5 lithiation of the 1-methyl>-6-(phenylthio)uracil (41) with LTMP or the LDA lithiation of 5-alkyl-1-methyl>-2-thiouracil derivatives 45-47.Substitution at the meta position of the C-6-(phenylthio) ring by the methyl group improved the original anti-HIV-1 activity of HEPT, and introduction of two m-methyl groups to the phenylthio ring further potentiated the activity -1-thymine (28), 0.26 μM; 6--1--2-thiothymine (30), 0.22 μM>.When the 5-methyl group was replaced by an ethyl or an isopropyl group, the anti-HIV-1 activity of HEPT was also improved remarkably -6-(phenylthio)-2-thiouracil (48), 0.11 μM; 5-isopropyl-1--6-(phenylthio)-2-thiouracil (50), 0.059 μM; 5-ethyl-1--6-(phenylthio)-2-thiouracil (54), 0.12 μM; 5-isopropyl-1--6-(phenylthio)-2-thiouracil (56), 0.063 μM>. 6--5-ethyl-1-thymine derivatives 51 and 57 and 6--5-isopropyl-1-thymine derivatives 52 and 58 inhibited the replication of HIV-1 in the nanomolar concentration range.
