125078-15-1

Basic information

• Product Name: (1-AMINO-2,2-DIMETHYLPROPYL)PHOSPHONIC ACID HYDRATE
• Synonyms: (1-AMINO-2,2-DIMETHYLPROPYL)PHOSPHONIC ACID;(1-AMINO-2,2-DIMETHYLPROPYL)PHOSPHONIC ACID HYDRATE;(1-AMINO-2,2-DIMETHYLPROPYL)PHOSPHONIC ACID HYDRATE 97%;(1-Amino-2,2-dimethylpropyl)phosphonic acid hydrate,97%
• CAS NO: 125078-15-1
• Molecular Formula: C5H14NO3P
• Molecular Weight: 167.14
• Mol File: 125078-15-1.mol

Chemical Properties

• Melting Point: 245-252 °C
• Boiling Point: 305.2°C at 760 mmHg
• Flash Point: 138.4°C
• Appearance: /
• Density: 1.244±0.06 g/cm3(Predicted)
• Vapor Pressure: 0.00019mmHg at 25°C
• PKA: 0.95±0.10(Predicted)
• CAS DataBase Reference: (1-AMINO-2,2-DIMETHYLPROPYL)PHOSPHONIC ACID HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: (1-AMINO-2,2-DIMETHYLPROPYL)PHOSPHONIC ACID HYDRATE(125078-15-1)
• EPA Substance Registry System: (1-AMINO-2,2-DIMETHYLPROPYL)PHOSPHONIC ACID HYDRATE(125078-15-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• Hazardous Substances Data: 125078-15-1(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

InChI:InChI=1/C5H14NO3P/c1-5(2,3)4(6)10(7,8)9/h4H,6H2,1-3H3,(H2,7,8,9)/p-1/t4-/m0/s1

Upstream product

• 129216-65-5 N-(1-Acetylamino-2,2-dimethyl-propyl)-acetamide 
• 630-19-3 pivalaldehyde 
• 125889-01-2 bis(trimethylsilyl)-N-benzyl-2,2-dimethylpropanimidoyl phosphonate 
• 125889-00-1 N-(1-chloro-2,2-dimethylpropylidene)benzylamine 
• 125889-02-3 bis(trimethylsilyl)-N-benzylideneamino-2,2-dimethylpropyl phosphonate 

Relevant articles and documents

Sigmatropic isomerizations in azaallyl systems: XXI. Alkanimidoylphosphonates and their prototropic and phosphorotropic isomers

Synthetic procedures for alkanimidoylphosphoryl derivatives with α-hydrogen atoms in the N-alkyl radical are developed. Data on the effect of substituents at the carbon and phosphorus atoms on the facility of prototropic transitions in the C=N-C triad are

The Synthesis of 1-Aminoalkylphosphonic Acids. A Revised Mechanism of the Reaction of Phosphorus Trichloride, Amides and Aldehydes or Ketones in Acetic Acid (Oleksyszyn Reaction)

The mechanism of the amidoalkylation of trivalent phosphorus compounds in acetic acid has been reinvestigated.Evidence is presented that 1-(acylamino)alkyl acetates 5 and not N,N'-alkylidenebisamides 2 are the intermediates in this reaction.Supporting literature analogies are discussed.This paper also describes a convenient procedure for the preparation of crude (acylamino)alkyl alkanoates 5, which are excellent amidoalkylating agents.The usefulness of these reagents is demonstrated by a simple two-step "one pot" synthesis of 1-aminoalkylphosphinic acids 1.

Synthesis of 1-Aminoalkylphosphonic Acids via Amidoalkylation of Phosphorous Acid by N,N'-Alkylidenbisamides

N,N'-Alkylidenebisamides 1, totally unsuitable as amidoalkylating agents toward phosphorous acid, react with its "activated" form prepared "in situ" from phosphorous(III) chloride and acetic acid to give the desired 1-amidoalkylphosphonic acids 2 in high yield.