125090-24-6Relevant articles and documents
Synergistic Cu/Pd Catalysis for Enantioselective Allylic Alkylation of Aldimine Esters: Access to α,α-Disubstituted α-Amino Acids
Wei, Liang,Xu, Shi-Ming,Zhu, Qiao,Che, Chao,Wang, Chun-Jiang
, p. 12312 - 12316 (2017)
An unprecedented enantioselective allylic alkylation of readily available aldimine esters has been developed, and is catalyzed by a synergistic Cu/Pd catalyst system. This strategy provides facile access to nonproteinogenic α,α-disubstituted α-amino acids in high yield with excellent enantioselectivity. The more challenging double allylic alkylation of glycinate-derived imine esters was also realized. Furthermore, this methodology was applied for the construction of the key intermediate of PLG peptidomimetics.
SYNTHESIS OF NONPROTEINOGENIC AMINO ACIDS PART 3: CONVERSION OF GLUTAMIC ACID INTO γ,δ-UNSATURATED α-AMINO ACIDS.
Baldwin, Jack E.,North, Michael,Flinn, Anthony,Moloney, Mark G.
, p. 1465 - 1474 (2007/10/02)
A general procedure for the asymmetric synthesis of γ,δ-unsaturated α-amino acids (7) from the γ-anion derived from (S)-glutamic acid is described.
