66646-88-6

Basic information

• Product Name: METHYL ((PHENYLMETHYLIDENE)AMINO ACETAT&
• Synonyms: METHYL ((PHENYLMETHYLIDENE)AMINO ACETAT&;Glycine, N-(phenylMethylene)-, Methyl ester;Methyl 2-(benzylideneaMino)acetate
• CAS NO: 66646-88-6
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.202
• Product Categories: C10 to C11;Carbonyl Compounds;Esters
• Mol File: 66646-88-6.mol
• Article Data: 96

Chemical Properties

• Boiling Point: 94-100 °C0.15 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.104 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0152mmHg at 25°C
• Refractive Index: n20/D 1.5480(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.70±0.50(Predicted)
• CAS DataBase Reference: METHYL ((PHENYLMETHYLIDENE)AMINO ACETAT&(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL ((PHENYLMETHYLIDENE)AMINO ACETAT&(66646-88-6)
• EPA Substance Registry System: METHYL ((PHENYLMETHYLIDENE)AMINO ACETAT&(66646-88-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 66646-88-6(Hazardous Substances Data)

Usage

General Description

Methyl ((phenylmethylidene)amino acetate, also known as Methyl benzylidene amino acetate, is a chemical compound with the molecular formula C10H11NO2. It is a derivative of amino acids and has potential applications in the pharmaceutical and medical industries. METHYL ((PHENYLMETHYLIDENE)AMINO ACETAT& is known to possess antioxidant and anti-inflammatory properties, making it a potential candidate for the development of new drugs for the treatment of various medical conditions. Additionally, it has been studied for its potential role in promoting muscle growth and improving exercise performance. However, further research is needed to fully understand its potential uses and effects.

InChI:InChI=1/C10H11NO2/c1-13-10(12)8-11-7-9-5-3-2-4-6-9/h2-7H,8H2,1H3/b11-7+

Upstream product

• 5680-79-5 glycine ethyl ester hydrochloride 
• 100-52-7 benzaldehyde 
• 616-34-2 methoxycarbonylmethylamine 
• 6000-43-7 2-aminoethanoic acid hydrochloride 
• 922-68-9 Methyl glyoxylate 
• 100-46-9 benzylamine 

Downstream Products

• 111098-98-7 methyl (1SR,3RS,3aSR,6aRS)-5-methyl-4,6-dioxo-3-phenyloctahydropyrrolo[3,4-c]pyrrole-1-carboxylate 
• 111098-98-7 methyl (1RS,3RS,3aSR,6aRS)-5-methyl-4,6-dioxo-3-phenyloctahydropyrrolo[3,4-c]pyrrole-1-carboxylate 
• 113273-65-7 tert-butyl (+/-)-(2S,4S,5R)-2-methoxycarbonyl-5-phenylpyrrolidine-4-carboxylate 
• 479499-52-0 (2S,4S,5R)-dimethyl 5-phenylpyrrolidine-2,4-dicarboxylate 
• 112575-34-5 N-benzylidene-2,3-methanohomoserine γ-lactone 
• 69994-51-0 trimethyl (2SR,3SR,4SR,5RS)-5-phenylpyrrolidine-2,3,4-tricarboxylate 
• 113273-71-5 (2S,3R,4S,5R)-4-Acetyl-3,5-diphenyl-pyrrolidine-2-carboxylic acid methyl ester 
• 113273-68-0 (2R,4R,5R)-4-Methyl-5-phenyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 138495-08-6 3-Methoxy-2-phenyl-3-trimethylsilanyloxy-azetidine-1-carboxylic acid methyl ester 
• 75516-84-6 (+/-)-(2R,4R,5S)-dimethyl 5-phenylpyrrolidine-2,4-dicarboxylate 

Relevant articles and documents

A powerful azomethine ylide route mediated by TiO2photocatalysis for the preparation of polysubstituted imidazolidines

Lewis- and Br?nsted-acid catalyzed 1,3-dipolar cycloaddition between azomethine ylides and unsaturated compounds is an important strategy to construct five-membered N-heterocycles. However, such a catalytic route usually demands substrates with an electron-withdrawing group (EWG) to facilitate the reactivity. Herein, we report a TiO2photocatalysis strategy that can conveniently prepare five-membered N-heterocyclic imidazolidines from a common imine (N-benzylidenebenzylamine) and alcohols along the route of 1,3-dipolaron azomethine ylide but without pre-installed EWG substituents on the substrates. Our EPR results uncovered the previously unknown mutual interdependence between an azomethine ylide and TiO2photo-induced hvb+/ecb?pair. This transformation exhibited a broad scope with 21 successful examples and could be scaled up to the gram level.

Highly diastereoselective multicomponent synthesis of unsymmetrical imidazolines.

We report here a highly diastereoselective multicomponent synthesis of imidazolines. These low molecular weight scaffolds contain a four-point diversity applicable to alkyl, aryl, acyl, and hetereocyclic substitutions. [structure: see text]

Copper/GanPhos-Catalyzed 1,3-Dipolar Cycloaddition of Azo?-methine Ylides: An Efficient Access to Chiral Pyrrolidine Spirocycles

A highly efficient copper/GanPhos-catalyzed 1,3-dipolar cyclo?-addition?-of azomethine ylides is reported. This viable transformation provides a series of optically active spiro[dihydronaphthalene-2,3′-pyrrolidine]s, bearing one spiro quaternary and three tertiary stereogenic centers, in good yields and with high ee values. This protocol features high diastereo- A nd enantioselectivity, broad substrate scope and mild reaction conditions.

Tunable Synthesis of α-Amino Boronic Esters from Available Aldehydes and Amines through Sequential One-Pot Dehydration and Copper-Catalyzed Borylacylation

Copper-catalyzed multicomponent borylacylation of imines with acid chlorides and bis(pinacolato)diboron was developed for the preparation of synthetically useful and pharmacologically relevant α-amino boronic acid derivatives. Starting from a range of acid chlorides and imines with aryl, heteroaryl, and alkyl substituents, most of these ligand-free reactions proceeded smoothly at room temperature in moderate to good yields. Furthermore, a facile and convenient one-pot, multistep access to the direct synthesis of α-amino boronic acid derivatives from available aldehydes and amines was also developed.