1250965-42-4Relevant articles and documents
Fragment-based discovery and optimization of BACE1 inhibitors
Madden, James,Dod, Jenny R.,Godemann, Robert,Kraemer, Joachim,Smith, Myron,Biniszkiewicz, Marion,Hallett, David J.,Barker, John,Dyekjaer, Jane D.,Hesterkamp, Thomas
scheme or table, p. 5329 - 5333 (2010/10/19)
A novel series of 2-aminobenzimidazole inhibitors of BACE1 has been discovered using fragment-based drug discovery (FBDD) techniques. The rapid optimization of these inhibitors using structure-guided medicinal chemistry is discussed.