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17083-26-0

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17083-26-0 Usage

General Description

H-SER(TBU)-OME HCL, also known as N-(tert-Butyloxycarbonyl)-L-serine methyl ester hydrochloride, is a chemical compound commonly used in peptide synthesis and pharmaceutical research. It is a derivative of serine, an amino acid essential for protein synthesis and the function of biological enzymes. H-SER(TBU)-OME HCL is typically used as a building block in the production of peptides and can also be employed as a modifying agent to alter the structure and function of peptides. Its hydrochloride form improves its solubility in polar solvents and makes it more suitable for a wide range of chemical reactions and applications in the laboratory.

Check Digit Verification of cas no

The CAS Registry Mumber 17083-26-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,0,8 and 3 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 17083-26:
(7*1)+(6*7)+(5*0)+(4*8)+(3*3)+(2*2)+(1*6)=100
100 % 10 = 0
So 17083-26-0 is a valid CAS Registry Number.

17083-26-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl (2S)-2-amino-3-[(2-methylpropan-2-yl)oxy]propanoate

1.2 Other means of identification

Product number -
Other names MMJPLCPGTJXFNH-LURJTMIESA

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17083-26-0 SDS

17083-26-0Relevant articles and documents

Preparation method of fmoc-O-tert-butyl-L-serine

-

Paragraph 0005; 0024; 0025; 0027; 0031; 0033; 0036; 0038, (2019/02/17)

The invention discloses a preparation method of fmoc-O-tert-butyl-L-serine. The method comprises the steps that 1, L-serine and a methanol solution are added into a reaction container, and under stirring, SOCl2 is added dropwise for reflux reaction to obtain L-serine methyl ester hydrochloride; 2, the L-serine methyl ester hydrochloride is added into tert-butyl acetate, and a catalyst is added forreaction to obtain O-tert-butyl-L-serine methyl ester; 3, the O-tert-butyl-L-serine methyl ester is added into alkaline liquid for saponification reaction to obtain an O-tert-butyl-L-serine aqueous solution; 4, an organic solvent and NaCO3 are added into O-tert-butyl-L-serine, then fmoc n-hydroxysuccinimide este is added to adjust a pH value to be 8-10, and extraction separation is conducted to obtain the fmoc-O-tert-butyl-L-serine. In the preparation method, the L-serine, methanol and SOCl2 are adopted as raw materials, and through the reflux reaction, the L-serine methyl ester hydrochlorideis prepared; the reaction is carried out in liquid phases respectively, and is safe and pollution-free.

Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of Type 2 diabetes: 2. Optimization of serine and threonine ether amino acid residues

Sparks, Steven M.,Banker, Pierette,Bickett, David M.,Clancy, Daphne C.,Dickerson, Scott H.,Garrido, Dulce M.,Golden, Pamela L.,Peat, Andrew J.,Sheckler, Lauren R.,Tavares, Francis X.,Thomson, Stephen A.,Weiel, James E.

scheme or table, p. 981 - 985 (2009/08/15)

Optimization of the amino acid residue of a series of anthranilimide-based glycogen phosphorylase inhibitors is described leading to the identification of serine and threonine ether analogs. t-Butylthreonine analog 20 displayed potent in vitro inhibition of GPa, low potential for P450 inhibition, and excellent pharmacokinetic properties.

Novel conformationally constrained analogues of diacylglycerol. Protein kinase C binding affinity of simplified compounds based on a 6-membered lactam moiety

Endo, Yasuyuki,Hirano, Masaaki,Driedger, Paul E.,Stabel, Silvia,Shudo, Koichi

, p. 2997 - 3000 (2007/10/03)

Four configurational isomers of 6-hydroxymethyl-3-isopropyl-4-tetradecylpiperazin-2-ones (4-7), which were designed based on information obtained from the biologically active conformation of teleocidins and benzolactams, were synthesized and evaluated for

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