125127-48-2

Upstream product

• 45120-30-7 L-glutamic acid α-tert-butyl ester 
• 76-83-5 trityl chloride 
• 158805-13-1 α-tert-butyl γ-allyl N-trityl-L-glutamate 

Downstream Products

• 118545-50-9 α-tert-butyl γ-methyl N-trityl-L-glutamate 

Relevant academic research and scientific papers

AMINO DIACIDS CONTAINING PEPTIDE MODIFIERS

The present invention relates to peptide modifier compounds of Formula (1), or a salt thereof, wherein: a is an integer from 1 to 10, more preferably from 1 to 3; b is an integer from 0 to 7; Z is a terminal group and Y is a bivalent group. Further aspects of the invention relate to intermediates in the preparation of compounds of Formula (1), and the use of compounds of Formula 1 in the synthesis of peptide derivatives.

Convenient preparation of α-tert-butyl N-blocked glutamates through γ-allyl ester protection

Utilisation of γ-allyl ester protection of glutamates provides a convenient route to the synthesis of Z-Glu-OBu(t), Tr-Glu-OBu(t) and (Boc)2-Glu-OBu(t).