1251530-75-2Relevant academic research and scientific papers
Novel Notch-sparing γ-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library
Kurosumi, Motonori,Nishio, Yoshino,Osawa, Satoko,Kobayashi, Hisayoshi,Iwatsubo, Takeshi,Tomita, Taisuke,Miyachi, Hiroyuki
, p. 5282 - 5285 (2010)
Screening of our library of peroxisome proliferator-activated receptor (PPAR) agonists yielded several phenylpropanoic acid-derived γ-secretase inhibitors (GSIs). Structure-activity relationship studies indicated that (R)-configuration of α-substituted phenylpropanoic acid structure and cinnamic acid structure is favorable to prepare Notch-sparing GSIs.
