125154-08-7Relevant academic research and scientific papers
Thiourea derivatives, methods of their preparation and their use in neutron capture therapy of malignant melanoma
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, (2008/06/13)
The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy.
Boron-Containing Thiouracil Derivatives for Neutron-Capture Therapy of Melanoma
Tjarks, Werner,Gabel, Detlef
, p. 315 - 319 (2007/10/02)
Boron-containing derivatives of 2-thiouracil and 2,4-dithiouracil and the corresponding 6-propyl compounds, containing a dihydroxyboryl group in the 5-position, have been prepared.These compounds accumulate in B16 melanoma in mice in concentrations up to 30 μg of boron per gram tissue.The uptake persists.The toxicity of both 2-thiouracil derivatives is low.These compounds are therefore good candidates for boron neutron-capture therapy of malignant melanoma.
