125191-23-3Relevant academic research and scientific papers
Renin inhibitors containing α-heteroatom amino acids as P2 residues
Repine,Kaltenbronn,Doherty,Hamby,Himmelsbach,Kornberg,Taylor,Lunney,Humblet,Rapundalo,Batley,Ryan,Painchaud
, p. 1032 - 1042 (2007/10/02)
A series of renin inhibitors having α-heteroatom amino acids as P2 substitutions has been prepared. Examples where the heteroatom is oxygen, sulfur, or nitrogen are described. Many of the compounds exhibit subnanomolar potency when tested in vi
