1251957-86-4

Basic information

• Product Name: 2-[4-(2-{[(2R)-2-(6-chloropyridin-3-yl)-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide
• Synonyms: 2-[4-(2-{[(2R)-2-(6-chloropyridin-3-yl)-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide
• CAS NO: 1251957-86-4
• Molecular Weight: 442.945
• Mol File: 1251957-86-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[4-(2-{[(2R)-2-(6-chloropyridin-3-yl)-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(2-{[(2R)-2-(6-chloropyridin-3-yl)-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide(1251957-86-4)
• EPA Substance Registry System: 2-[4-(2-{[(2R)-2-(6-chloropyridin-3-yl)-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide(1251957-86-4)

Safety Data

• Hazardous Substances Data: 1251957-86-4(Hazardous Substances Data)

Upstream product

• 53939-30-3 5-bromo-2-chloropyridine 
• 88594-72-3 [4-(2-oxopropyl)phenyl]acetic acid 
• 861448-74-0 [4-(2-hydroxy-2-methylpropyl)phenyl]acetic acid 
• 1251957-82-0 2-[4-(2-hydroxy-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide 
• 1251957-83-1 2-chloro-N-[1,1-dimethyl-2-(4-{2-[(5-methylisoxazol-3-yl)amino]-2-oxoethyl}phenyl)ethyl]acetamide 
• 1251957-84-2 2-[4-(2-amino-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide 
• 173901-08-1 2-chloro-5-[(2R)-oxiran-2-yl]pyridine 
• 477259-60-2 (1R)-2-chloro-1-(6-chloropyridin-3-yl)ethanol 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 84541-92-4 methyl [4-(2-oxopropyl)phenyl]acetate 
• 136592-00-2 2-chloro-1-(6-chloropyridin-3-yl)ethanone 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 36076-25-2 (4-methoxycarbonylmethylphenyl)acetic acid methyl ester 
• 17833-56-6 ester monomethylique de l'acide p-phenylene diacetique 

Downstream Products

• 1251957-87-5 2-[4-(2-{[(2R)-2-hydroxy-2-(pyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide 

Relevant articles and documents

Application of biocatalysis towards asymmetric reduction and hydrolytic desymmetrisation in the synthesis of a β-3 receptor agonist

Chemoenzymatic syntheses of two key intermediates in the preparation of a potent β-3 receptor agonist 1 are described. A lipase-catalysed hydrolytic desymmetrisation is employed in a new synthesis of intermediate 7, which avoids the use of alkyl-tin reagents. A second biotransformation delivers chiral chlorohydrin 5 from its parent ketone in greater enantiomeric excess than the previously-described Noyori-reduction process. A brief discussion of the enantioselectivity of a set of single-point mutants of Sporobolomyces salmonicolor aldehyde reductase in this bioreduction is also presented.