17833-56-6

Upstream product

• 7325-46-4 1,4-phenylenediacetic acid 
• 622-75-3 1,4-phenylenediacetonitrile 
• 36076-25-2 (4-methoxycarbonylmethylphenyl)acetic acid methyl ester 

Downstream Products

• 1251957-87-5 2-[4-(2-{[(2R)-2-hydroxy-2-(pyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide 
• 1251957-82-0 2-[4-(2-hydroxy-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide 
• 1251957-84-2 2-[4-(2-amino-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide 
• 1251957-86-4 2-[4-(2-{[(2R)-2-(6-chloropyridin-3-yl)-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide 
• 861448-74-0 [4-(2-hydroxy-2-methylpropyl)phenyl]acetic acid 
• 129506-80-5 methyl 2-[4-(2-hydroxyethyl)phenyl]acetate 
• 191871-32-6 [4-(tert-butoxycarbonylamino-methyl)-phenyl]-acetic acid methyl ester 
• 96524-70-8 methyl 2-(4-formylphenyl)acetate 
• 282088-96-4 4-[[[4-[[[4-[[p-(methoxycarbonyl)phenylenecarbonyl]amino]-1-methyl-2-pyrrolyl]carbonyl]amino]-1-methyl-2-pyrrolyl]carbonyl]amino]-1-methyl-N-[3-(N,N-dimethylamino)propyl]-2-pyrrolecarboxamide 
• 4253-33-2 bibenzyl-4,4'-diyl-di-acetic acid dimethyl ester 
• 115414-80-7 (4-Methoxymethyl-phenyl)-acetic acid methyl ester 
• 120167-84-2 bis (N-dodecyl acetamido)-1,4 butane 

Relevant academic research and scientific papers

Cyclic tris-[5]helicenes with single and triple twisted M?bius topologies and M?bius aromaticity

A number of singly (180°) twisted, largely single-stranded and thus conformationally rather fragile, M?bius molecules have been synthesized within the last 15 years, which are aromatic with 4n electrons, thus violating the Hückel rule. Annulenes with sign

BIARYL COMPOUND, PREPARATION METHOD AND USE THEREFOR

The present invention belongs to the technical field of chemical pharmaceuticals, and relates to a compound represented by general formula (I) or formula (II) and a preparation method thereof. The compounds are biaryl derivatives with RORγt activation activity. The biaryl derivatives disclosed in this invention can effectively activate the RORγt protein receptor, and thereby promote the differentiation of Th17 cells and increasing the production of IL-17, which can be used as an immune modulator for the treatment of various cancers or viral infection-related diseases.

Application of biocatalysis towards asymmetric reduction and hydrolytic desymmetrisation in the synthesis of a β-3 receptor agonist

Chemoenzymatic syntheses of two key intermediates in the preparation of a potent β-3 receptor agonist 1 are described. A lipase-catalysed hydrolytic desymmetrisation is employed in a new synthesis of intermediate 7, which avoids the use of alkyl-tin reagents. A second biotransformation delivers chiral chlorohydrin 5 from its parent ketone in greater enantiomeric excess than the previously-described Noyori-reduction process. A brief discussion of the enantioselectivity of a set of single-point mutants of Sporobolomyces salmonicolor aldehyde reductase in this bioreduction is also presented.

PYRROLIDINE DERIVATIVE OR SALT THEREOF

[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).