17833-56-6Relevant articles and documents
Cyclic tris-[5]helicenes with single and triple twisted M?bius topologies and M?bius aromaticity
Naulet, Guillaume,Sturm, Ludmilla,Robert, Antoine,Dechambenoit, Pierre,R?hricht, Fynn,Herges, Rainer,Bock, Harald,Durola, Fabien
, p. 8930 - 8936 (2018)
A number of singly (180°) twisted, largely single-stranded and thus conformationally rather fragile, M?bius molecules have been synthesized within the last 15 years, which are aromatic with 4n electrons, thus violating the Hückel rule. Annulenes with sign
Application of biocatalysis towards asymmetric reduction and hydrolytic desymmetrisation in the synthesis of a β-3 receptor agonist
Badland, Matthew,Burns, Michael P.,Carroll, Robert J.,Howard, Roger M.,Laity, Daniel,Wymer, Nathan J.
, p. 2888 - 2894 (2011/12/05)
Chemoenzymatic syntheses of two key intermediates in the preparation of a potent β-3 receptor agonist 1 are described. A lipase-catalysed hydrolytic desymmetrisation is employed in a new synthesis of intermediate 7, which avoids the use of alkyl-tin reagents. A second biotransformation delivers chiral chlorohydrin 5 from its parent ketone in greater enantiomeric excess than the previously-described Noyori-reduction process. A brief discussion of the enantioselectivity of a set of single-point mutants of Sporobolomyces salmonicolor aldehyde reductase in this bioreduction is also presented.