125198-07-4Relevant academic research and scientific papers
Preparation of 2,3,4,5-tetrahydropyridines from 5-alkynylamines under the catalytic action of gold(III) salts
Fukuda,Utimoto
, p. 975 - 978 (1991)
Intramolecular addition of amine to carbon-carbon triple bonds in 5-alkynylamines produces 2,3,4,5-tetrahydropyridines under the catalytic action of an aurate salt. Some venom components of various ant species are synthesized by the application of this re
First Total Synthesis of Ganglioside GAA-7 from Starfish Asterias amurensis versicolor
Tamai, Hideki,Imamura, Akihiro,Ogawa, Junya,Ando, Hiromune,Ishida, Hideharu,Kiso, Makoto
, p. 5199 - 5211 (2015/08/18)
The first total synthesis of neuritogenic ganglioside GAA-7 was achieved using the glucosyl ceramide (Glc-Cer) cassette approach. The stereocenter triad within the ceramide moiety of the target molecule was efficiently established from D-lyxose. The assem
Palladium-Catalyzed Intramolecular Addition of Amines to Acetylenes. Synthesis of Cyclic Imines
Fukuda, Yukitoshi,Matsubara, Seijiro,Utimoto, Kiitiro
, p. 5812 - 5816 (2007/10/02)
Intramolecular aminopalladation of alkynylamines gave intermediary alkenylpalladium compounds that hydrolyzed and isomerized to thermodynamically stable cyclic imines.Treatment of 3-alkynylamines with a catalytic amount of PdCl2(MeCN)2 gave exclusively 1-
Design, Synthesis, and 5-Lipoxygenase-Inhibiting Properties of 1-Thio-Substiuted Butadienes
Hanko, Rudolf,Hammond, Michael D.,Fruchtmann, Romanis,Pfitzner, Joerg,Place, Graham A.
, p. 1163 - 1170 (2007/10/02)
The synthesis of novel 1-thio-substituted butadienes, designed as mechanism-based 5-lipoxygenase inhibitors, is described.The structure of these compounds closely resembles a proposed high-energy intermediate during the lipoxygenation of arachidonic acid.They demonstrate 5-lipoxygenase inhibition in vitro and in vivo.The most potent compound is 15a with an IC50 of μM in vitro.LTC4 release was inhibited by 80percent after intraperitoneal administration of 15c at a dose of 2 mg/kg.
