90486-47-8Relevant academic research and scientific papers
First Total Synthesis of Ganglioside GAA-7 from Starfish Asterias amurensis versicolor
Tamai, Hideki,Imamura, Akihiro,Ogawa, Junya,Ando, Hiromune,Ishida, Hideharu,Kiso, Makoto
, p. 5199 - 5211 (2015/08/18)
The first total synthesis of neuritogenic ganglioside GAA-7 was achieved using the glucosyl ceramide (Glc-Cer) cassette approach. The stereocenter triad within the ceramide moiety of the target molecule was efficiently established from D-lyxose. The assem
Design, Synthesis, and 5-Lipoxygenase-Inhibiting Properties of 1-Thio-Substiuted Butadienes
Hanko, Rudolf,Hammond, Michael D.,Fruchtmann, Romanis,Pfitzner, Joerg,Place, Graham A.
, p. 1163 - 1170 (2007/10/02)
The synthesis of novel 1-thio-substituted butadienes, designed as mechanism-based 5-lipoxygenase inhibitors, is described.The structure of these compounds closely resembles a proposed high-energy intermediate during the lipoxygenation of arachidonic acid.They demonstrate 5-lipoxygenase inhibition in vitro and in vivo.The most potent compound is 15a with an IC50 of μM in vitro.LTC4 release was inhibited by 80percent after intraperitoneal administration of 15c at a dose of 2 mg/kg.
USE OF SULFUR AS A CHEMICAL CONNECTOR
Buist, Petr H.,Dimnik, Gerald P.
, p. 1457 - 1460 (2007/10/02)
Replacement of a methylene group by a sulfur atom at the 6-position of oleic acid does not prevent biomethylation at the olefinic bond.
