1252017-22-3Relevant academic research and scientific papers
Synthesis of some novel chalcones of phthalimidoester possessing good antiinflammatory and antimicrobial activity
Gaikwad, Kishor V.,Gaikwad, Sandip V.,Jadhav, Satish B.,Rathod, Shantilal D.
experimental part, p. 131 - 136 (2010/05/02)
A new series of methyl-2-[substituted benzylidine]-4-[2-(phthalimide) ethoxy] acetoacetate, 5a-h have been synthesized from the combination of methyl-4-[2-(phthalimido) ethoxy] acetoacetate, 3 and substituted benzaldehyde 4a-h which results in both anti-inflammatory and antimicrobial active compound. These compounds have been characterized by IR, 1H NMR, mass spectral and elemental analysis. These compounds have been subjected to preliminary anti-inflammatory screening using the carrageenan induced rat pow oedema model. Compounds 5a,b,c show marked activity comparable to indomethacin. Compounds 5a,b,c,g show significant antimicrobial activity.
