1252017-92-7Relevant academic research and scientific papers
Synthesis and crystal structure of (S)-2-((S)-2-(N-Ts-Amino)-3- methylbutanoyl)-3-(1H-indol-3-yl)-6-phenyl-3,4-dihydro-1,2,4-triazin-5(2H)-one
Egorov, Ilya N.,Rusinov, Vladimir L.,Slepukhin, Pavel A.,Chupakhin, Oleg N.
, p. 387 - 390 (2010)
The diastereoselective synthesis, NMR and X-ray structure of (S)-2-((S)-2-(N-Ts-amino)-3-methylbutanoyl)-3-(1H-indol-3-yl)-6-phenyl-3, 4-dihydro-1,2,4-triazin-5(2H)-one-a potential antivirus agent are reported. The compound crystallizes in the triclinic space group P1 with unit cell parameters: a = 5.9259(6) A, b = 9.6370(12) A, c = 12.9541(9) A, α = 109.210(9)°, β = 90.804(7)°, γ = 105.074(10)° and Z = 1.
Asymmetric induction in the reactions of azinones with C-nucleophiles
Chupakhin,Egorov,Rusinov,Slepukhin
experimental part, p. 991 - 1001 (2011/02/27)
Effect of acylating agents on the course of addition of C-nucleophiles to 1,2,4- and 1,3,5-triazinones, as well as to quinoxalin-2(1H)-one, was studied. A series of new azinone derivatives was obtained. A method for the preparation of diastereomerically pure addition products of indoles to 1,2,4-triazinones and quinoxalin-2(1H)-one in the presence of N-Ts-L-amino acid acyl chlorides was suggested.
