125216-87-7

Upstream product

• 142229-40-1 3-Methylene-5-phenyl-1-(1-phenyl-vinyl)-pyrrolidin-2-one 
• 125216-69-5 1-(4-methoxyphenyl)-3-methylene-5-phenylpyrrolidin-2-one 
• 120419-97-8 (E)-N-benzylidene-1,1,1-trimethylsilanamine 
• 55147-78-9 bis(bis(trimethylsilyl)amido)tin(II) 
• 17435-72-2 ethyl 2-bromomethyl-2-propenoate 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 196929-85-8 (R)-N-benzylidene-2-methylpropane-2-sulfinamide 
• 16118-22-2 benzylidenamine 
• 142229-41-2 (S)-4-((S)-2-Hydroxy-1-phenyl-ethylamino)-2-methylene-4-phenyl-butyric acid tert-butyl ester 
• 142229-46-7 (S)-4-((S)-2-Hydroxy-1-phenyl-ethylamino)-2-methylene-4-phenyl-butyric acid 
• 142229-43-4 (R)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-3-methylene-5-phenyl-pyrrolidin-2-one 
• 1086234-95-8 2-Benzylidenamino-2-phenylaethanol 
• 17599-61-0 N-benzylidene-1,1,1-trimethylsilanamine 

Downstream Products

• 125216-88-8 (S)-3-methylene-5-phenyl-2-pyrrolidinone 
• 1138440-85-3 1-t-butoxycarbonyl-3-methylene-5-phenylpyrrolidin-2-one 
• 1138441-15-2 3-methylene-5-phenyl-1-pivaloylpyrrolidin-2-one 

Relevant academic research and scientific papers

Enantioselective synthesis of α-methylene γ-butyrolactams using N-tert-butanesulfinamides

Indium-mediated coupling of ethyl 2-(bromomethyl)acrylate (1) and chiral N-tert-butanelsulfinylimines 2 ina saturated sodium bromide aqueous solution leads to N-tert-butanesulfinyl aminoesters 3 in high yields and diastereoselectivities. After column chro

Imine allylation using 2-alkoxycarbonyl allylboronates as an expedient three-component reaction to polysubstituted α-exo-methylene-γ-lactams

α-exo-Methylene-γ-lactams are key structural units in a wide variety of biologically active natural products. A concise route to the formation of polysubstituted α-exo-methylene-γ-lactams is described. In this three-component reaction, an imine is formed

Synthesis of monoorganotins and use as versatile reagents for organic synthesis

The direct and quantitative preparation of monoorganotins 2, 3, 4 and 11 starting from Lappert's stannylene 1 represents a general access to a new class of organotin reagents.Their reactivity and versatility in the field of organic synthesis is highlighted.The influence of the substituents bound to the tin atom is shown for various reactions such as nucleophilic addition onto carbonyl compounds, radical transfer of functionalized moieties and coupling reactions catalysed by transition metals. - Keywords: stannylene; monoorganotin; radical allylic transfer; palladium

Sterecontrolled preparation of chiral secondary α-methylene γ-lactams by addition of organozinc reagents derived from 2-(bromomethyl)acrylates to imines using β-aminoalcohols as chiral auxiliaries.

Stereocontrolled addition of isolated organozinc reagents 1, prepared from 2-(bromomethyl)acrylates to imines, can be achieved with d.e. ca. 100percent using β-amino alcohols as chiral auxiliaries.High yields of pure R or S secondary α-methylene γ-lactams

SYNTHESIS OF SECONDARY α-METHYLENE γ-LACTAMS

N-trimethylsilyl aldimines, on reaction with the isolated organozinc derivative of ethyl α-(bromomethyl)acrylate, afford secondary α-methylene γ-lactams with quite quantitative yields.