125216-69-5Relevant academic research and scientific papers
Umpolung synthesis of branched α-functionalized amines from imines via photocatalytic three-component reductive coupling reactions
Fuentes De Arriba, Angel L.,Urbitsch, Felix,Dixon, Darren J.
, p. 14434 - 14437 (2016/12/23)
A three component reductive coupling reaction of a (hetero)aromatic amine, a (hetero)aromatic aldehyde and an electron deficient olefin catalysed by eosin Y under green LED light irradiation, for the direct generation of γ-amino acid derivatives, is described. This new umpolung synthesis of amines, which exploits the high nucleophilicity of a putative α-amino radical intermediate, generated via single electron reduction of the in situ generated imine from the Hantzsch ester terminal reductant, is efficient, operationally simple, broad in scope and offers a complementary strategy to existing synthetic approaches.
SYNTHESIS OF SECONDARY α-METHYLENE γ-LACTAMS
Alami, Najat Ei,Belaud, Chantal,Villieras, Jean
, p. 2073 - 2082 (2007/10/02)
N-trimethylsilyl aldimines, on reaction with the isolated organozinc derivative of ethyl α-(bromomethyl)acrylate, afford secondary α-methylene γ-lactams with quite quantitative yields.
