125218-44-2

Upstream product

• 125218-36-2 Methanesulfonic acid (R)-1-((3aR,5S,6aR)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-3-phenyl-propyl ester 
• 125218-42-0 (3S,4S)-4-Azido-3-formyloxy-6-phenyl-hexanoic acid 
• 1589-82-8 phenylmagnesium bromide 
• 4005-46-3 3-deoxy-1,2-O-isopropylidene-D-glucose 
• 2457-93-4 (3aR,5S,6aR)-2,2-dimethyl-5-[(2R)-oxiran-2-yl]-3a,5,6,6a-tetrahydrofuro[2,3-d] [1,3]dioxole 

Downstream Products

• 724733-52-2 (3S,4S)-4-azido-3-hydroxy-6-phenylhexanoic acid [(S)-1-((S)-1-carbamoyl-3-methylbutylcarbamoyl)ethyl]amide 

Relevant academic research and scientific papers

Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs

Picomolar to low nanomolar inhibitors of the two aspartic proteases plasmepsin (Plm) I and II, from the malaria parasite Plasmodium falciparum, have been identified from sets of libraries containing novel statine-like templates modified at the amino and c

Synthesis of Statine and Its Analogues

Statine, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid, and its analogues were prepared from 5,6-anhydro-3-deoxy-1,2-O-isopropylidene-D-glucofuranose.The key step is the stereospecific reaction of the epoxy sugar with the Grignard reagent.