125219-60-5

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 2826-24-6 4-bromobenzylidenemalononitrile 
• 1122-91-4 4-bromo-benzaldehyde 
• 109-77-3 malononitrile 
• 107-10-8 propylamine 
• 75-15-0 carbon disulfide 
• 68029-54-9 (Z)-3-(4-Bromo-phenyl)-2-cyano-thioacrylamide 

Downstream Products

• 105648-24-6 6-amino-4-(4-bromophenyl)-3,5-dicyanopyridine-2(1H)-thione 
• 94833-60-0 2-(4-bromobenzoylmethylsulfanyl)-4-(4-bromophenyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile 
• 1110659-04-5 2-allylsulfanyl-4-(4-bromophenyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile 
• 94640-03-6 4-(4-bromophenyl)-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 208254-37-9 2-[6-Amino-4-(4-bromo-phenyl)-3,5-dicyano-pyridin-2-ylsulfanyl]-N-(4-bromo-phenyl)-acetamide 
• 208254-28-8 2-Amino-4-(4-bromo-phenyl)-6-[2-(4-bromo-phenyl)-2-oxo-ethylsulfanyl]-pyridine-3,5-dicarbonitrile 
• 208254-29-9 2-Amino-4-(4-bromo-phenyl)-6-[2-(4-chloro-phenyl)-2-oxo-ethylsulfanyl]-pyridine-3,5-dicarbonitrile 
• 208254-30-2 2-[6-Amino-4-(4-bromo-phenyl)-3,5-dicyano-pyridin-2-ylsulfanyl]-acetamide 

Relevant academic research and scientific papers

Multicomponent Synthesis of 4-Alkyl(Aryl, Hetaryl)-2-alkoxycarbonyl(aroyl, carbamoyl)- 3,6-diamino-5-cyanothieno[2,3-b]pyridines

The condensation of malononitrile with hydrogen sulfide and aldehydes in the presence of triethylamine in ethanol at room temperature afforded 4-alkyl(aryl, hetaryl)-2,6-diamino-3,5-dicyano-4H-thiopyrans. Treatment of the latter in situ with alkali in DMF, followed by addition of an alkylating agent, led to the formation of 4-alkyl(aryl, hetaryl)-2-alkoxycarbonyl(aroyl, carbamoyl)-3,6-diamino-5-cyanothieno[2,3-b]- pyridines.

Bis(4-pyridylamino)triazine-stabilized magnetite nanoparticles: preparation, characterization and application as a retrievable catalyst for the green synthesis of 4H-pyran, 4H-thiopyran and 1,4-dihydropyridine derivatives

Synthesis of bis(4-pyridylamino)triazine stabilized on silica-coated nano-Fe3O4 particles, and their feasibility as a reusable heterogeneous basic catalyst are reported. The catalytic performance of this novel material was studied fo

MWI-promoted preparation of 4H-thiopyran derivatives through one-pot multi-component reactions

One-pot reaction of aromatic aldehydes, cyanothioacetamide and malononitrile under microwave irradiation proved to be an efficient way for the synthesis of 2,6-diamino-4-aryl-4H-thiopyran-3,5-dicarbonitriles without any added catalyst.

CYCLIZATION OF NITRILES. XXXIII. SYNTHESIS AND STRUCTURE OF 4-ARYL-2,6-DIAMINO-3,5-DICYANOTHIOPYRANS AND THEIR RECYCLIZATION TO 6-AMINO-4-ARYL-3,5-DICYANO-2(1H)-PYRIDINETHIONES

Like the three-component condensation of aromatic aldehydes, malononitrile, and cyanothioacetamide, the reaction of arylidenemalononitriles with cyanothioacetamide and of arylidenecyanothioacetamides with malononitrile leads to the formation of 4-aryl-2,6-diamino-3,5-dicyano-4H-thiopyrans.It was established by x-ray crystallographic investigation that the 4H-thiopyran ring in the obtained compounds has the boat conformation.Under the influence of bases the 4H-thiopyrans readily undergo recyclization to 6-amino-4-aryl-3,5-dicyano-2(1H)-pyridinethiones.