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• 4467-06-5 2-(4-methylphenyl)pyridine 

Relevant academic research and scientific papers

Palladium-catalyzed chelation-assisted c-h bond halogenation: Selective chlorination of 2-arylpyridines with acid chlorides

Palladium-catalyzed chelation-assisted C-H bond halogenation of arenes using acid chlorides as chlorinating agents is reported. This method provides a monoselective, straightforward, and clean route for the construction of aryl chlorides as privileged mot

Salen-based hypercrosslinked polymer-supported Pd as an efficient and recyclable catalyst for C-H halogenation

In this work, we report the first use of a salen-based hypercrosslinked polymer-supported Pd catalyst to carry out C-H halogenation. This catalyst can effectively catalyze C-H bromination and chlorination even better than its homogeneous counterpart Pd(OAc)2. It also showed excellent reusability without loss of catalytic activity for ten cycles. A broad substrate scope was explored and moderate to excellent yields were obtained.

Cu-catalyzed direct ortho-chlorination/-oxygenation of aryls: Switching of oxidant, control the diversity of products

Highly regioselective copper catalyzed ortho-chlorination of aryl pyridines was achieved with TBHP as oxidant and 1,2-dichloroethane as chlorinating agent for the first time. Switching the oxidant from TBHP to benzoyl peroxide under identical reaction conditions effects ortho-oxygenation.

Copper(II)-Promoted Mono-Selective ortho C-H Chlorination of Arenes by Using Trimethyl(trichloromethyl)silane

The first example of a Cu-promoted ortho -chlorination of aryl C-H bonds by using TMSCCl 3 as chlorinating agent is reported. This reaction features a high selectivity toward monochlorination over dichlorination, compatibility with a variety of

Sodium halides as halogenating reagents: Rhodium(III)-catalyzed versatile and practical halogenation of aryl compounds

We report a concise, versatile and practical method for the ortho-chlorination, ortho-bromination and ortho -iodination of aryl compounds. The significant advantage of this transformation is the creation of the carbon-halogen bond by use of readily available and cheap halide salts as formal nucleoACHTUNGTRENUNGphilic halogenating reagents under mild reaction conditions.

Arylmethyl chlorides: New bifunctional reagents for palladium-catalyzed ortho -chlorination and acylation of 2-arylpyridines

A chemoselective, palladium-catalyzed, ligand-directed ortho-C-H chlorination and acylation process has been developed, exhibiting high regioselectivity for 2-arylpyridines bearing a meta-substituent. Worthy of note is the fact that arylmethyl chlorides a

Cu-mediated direct aryl C - H halogenation: A strategy to control mono- and di-selectivity

A protocol for the copper-mediated direct aryl C - H halogenation is presented. Highly selective mono- and di-halogenations are achieved by using acyl hypohalites, generated in situ from the readily available carboxylic acid and N-halosuccinimides (NXS; X=Br and Cl) as powerful halogenating reagents. The correct choice of carboxylic acid additives and solvents is essential for both high yield and selectivity. Consequently, the use of inexpensive Cu catalyst and the new strategy for the in situ generation of acyl hypohalite halogenating reagents from the readily affordable and easily-to-handle carboxylic acid and NXS (X=Br and Cl) offers advantages for practical application. Copyright

Copper-catalyzed aromatic C-H bond halogenation using lithium halides as halogenating reagents

The copper-catalyzed C-H halogenation of 2-aryl-pyridines containing a variety of electron-withdrawing and electron-donating substituents was described. It is worth noting that cheap and easy-to-handle lithium halides were utilized as the halogen sources. Georg Thieme Verlag Stuttgart · New York.

Preparation and C-X reductive elimination reactivity of monoaryl Pd IV-X complexes in water (X = OH, OH2, Cl, Br)

Monohydrocarbyl palladium(IV) complexes bearing OH, OH2, Br, and Cl ligands at the metal and supported by facially chelating 1-hydroxy-1,1-bis(2-pyridyl)methoxide were readily prepared in water at 0 °C. These complexes reductively eliminate Ar-