1252207-52-5

Upstream product

• 4467-06-5 2-(4-methylphenyl)pyridine 
• 1326720-87-9 2-(2-dibromoboryl-4-methylphenyl)pyridine 

Relevant academic research and scientific papers

Efficient Pd-Catalyzed C—H Oxidative Bromination of Arenes with Dimethyl Sulfoxide and Hydrobromic Acid?

We have developed an efficient Pd-catalyzed directed C—H bromination protocol, in which dimethyl sulfoxide (DMSO) is employed as oxidant with hydrobromic acid aqueous solution (HBr(aq)) as bromide source. The DMSO/HBr(aq) system, which is novelly and efficiently utilized in transition-metal catalyzed C—H activation, illustrates its practicability by the operational simplicity, inexpensive and readily available starting materials, and high bromide-atom economy.

Salen-based hypercrosslinked polymer-supported Pd as an efficient and recyclable catalyst for C-H halogenation

In this work, we report the first use of a salen-based hypercrosslinked polymer-supported Pd catalyst to carry out C-H halogenation. This catalyst can effectively catalyze C-H bromination and chlorination even better than its homogeneous counterpart Pd(OAc)2. It also showed excellent reusability without loss of catalytic activity for ten cycles. A broad substrate scope was explored and moderate to excellent yields were obtained.

Sodium halides as halogenating reagents: Rhodium(III)-catalyzed versatile and practical halogenation of aryl compounds

We report a concise, versatile and practical method for the ortho-chlorination, ortho-bromination and ortho -iodination of aryl compounds. The significant advantage of this transformation is the creation of the carbon-halogen bond by use of readily available and cheap halide salts as formal nucleoACHTUNGTRENUNGphilic halogenating reagents under mild reaction conditions.

Cu-mediated direct aryl C - H halogenation: A strategy to control mono- and di-selectivity

A protocol for the copper-mediated direct aryl C - H halogenation is presented. Highly selective mono- and di-halogenations are achieved by using acyl hypohalites, generated in situ from the readily available carboxylic acid and N-halosuccinimides (NXS; X=Br and Cl) as powerful halogenating reagents. The correct choice of carboxylic acid additives and solvents is essential for both high yield and selectivity. Consequently, the use of inexpensive Cu catalyst and the new strategy for the in situ generation of acyl hypohalite halogenating reagents from the readily affordable and easily-to-handle carboxylic acid and NXS (X=Br and Cl) offers advantages for practical application. Copyright

Functionalizations of aryl C-H bonds in 2-arylpyridines via sequential borylation and copper catalysis

Selective functionalizations of aryl C-H bonds in 2-arylpyridines have been developed via sequential borylation and aerobic oxidative copper catalysis, and the corresponding aryl halides, sulfones, azides and arylamines were obtained in good yields. The protocol uses cheap and readily available boron tribromide (BBr3) as the borylating reagent, and inorganic salts (potassium iodide, ammonium bromide, sodium alkylsulfinates, sodium azide) as the functional group sources. This method makes functionalizations of aryl C-H bonds easy. Copyright

Preparation and C-X reductive elimination reactivity of monoaryl Pd IV-X complexes in water (X = OH, OH2, Cl, Br)

Monohydrocarbyl palladium(IV) complexes bearing OH, OH2, Br, and Cl ligands at the metal and supported by facially chelating 1-hydroxy-1,1-bis(2-pyridyl)methoxide were readily prepared in water at 0 °C. These complexes reductively eliminate Ar-