125228-75-3

Upstream product

• 79-21-0 peracetic acid 
• 1568-66-7 1-allyloxy-4-nitrobenzene 
• 100-02-7 4-nitro-phenol 
• 96-23-1 1,3-Dichloro-2-propanol 
• 106-89-8 epichlorohydrin 
• 34211-48-8 1,2-dihydroxy-3-(4-nitrophenyloxy)-propane 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 505-18-0 2,3,4,5-tetrahydropyridine 
• 152333-94-3 glycidyl nosylate 
• 824-78-2 4-nitrophenol sodium salt 
• 115314-14-2 (2S)-(+)-glycidyl 3-nitrobenzenesulfonate 
• 118629-64-4 4-nitro-benzenesulfonic acid oxiranylmethyl ester 

Downstream Products

• 55883-23-3 1-(4-nitro-phenoxy)-3-piperidino-propan-2-ol 
• 59117-66-7 N-[2-hydroxy-3-(4-nitro-phenoxy)-propyl]-succinimide 
• 94662-07-4 N-[2-hydroxy-3-(4-nitro-phenoxy)-propyl]-phthalimide 
• 133228-94-1 1-methylamino-3-(4-nitro-phenoxy)-propan-2-ol 
• 70133-12-9 3-(4-nitro-anilino)-propane-1,2-diol 
• 5255-92-5 5-(4-nitro-phenoxymethyl)-3-phenyl-oxazolidin-2-one 
• 133228-95-2 1-(4-Nitrophenoxy)-3-(tert-butylamino)-propan-2-ol 
• 133229-06-8 1-(4-Nitrophenoxy)-3-(1,2,3,4-tetrahydroisoquinolino)-propan-2-ol 
• 64511-67-7 1-(4-nitrophenoxy)-3-(N-4-phenylpiperidine)-2-propanol 
• 102096-47-9 1-(6-Methoxy-quinolin-8-ylamino)-3-(4-nitro-phenoxy)-propan-2-ol 
• 757156-67-5 1-(4-Nitro-phenoxy)-3-(4-pyrimidin-2-yl-piperazin-1-yl)-propan-2-ol 
• 133229-04-6 1-[4-(4-Chloro-phenyl)-piperidin-1-yl]-3-(4-nitro-phenoxy)-propan-2-ol 
• 65911-02-6 1,3-Di-(4-nitrophenoxy)-2-propanol 
• 93624-95-4 5-(4-Nitro-phenoxymethyl)-[1,4,2]dioxazinan-3-one 

Relevant academic research and scientific papers

Synthesis and optical storage properties of a thiophene-based holographic recording medium

The results of the fabrication and optical data storage characteristics of a novel azothiophene polyester 9 for potential holographic storage are reported. The polyester is derived from an azothiophene diol 1 and diphenyl phthalate 8 via in vacuo melt transesterification. Inclusion of a 5-methoxy-2-thienyl moiety generates a trans π-π* transition centered close to 405 nm. An investigation of the optical data storage characteristics of a solution cast film of azopolyester with a thickness of 65 m is summarised. The optical anisotropy induced by a 532 nm frequency doubled YAG laser and probed at a wavelength of 633 nm outside the absorption band with a polarimeter reveals a very high induced anisotropy of 7 rad (laser intensity, 250 mW cm-2). The calculated birefringence of the film is 0.02 per micron. Maximum anisotropy is reached after approximately 70 s of irradiation. The induced anisotropy disappears at approximately 90 °C. Room temperature stable gratings can be inscribed with high diffraction efficiency. The Royal Society of Chemistry 2007.

Chemoselective Epoxidation of Allyloxybenzene by Hydrogen Peroxide Over MFI-Type Titanosilicate

The chemoselective synthesis of 2-(phenoxymethyl)oxirane from allyloxybenzene is achieved with over 90 % yield in a sustainable reaction system using titanium-substituted silicalite-1 (TS-1) as a catalyst, hydrogen peroxide (H2O2) as an oxidant, and a mixture of MeOH/MeCN as a solvent at 40 °C. No acid-catalyzed side reactions prompted by the Lewis acidity of the Ti active site in TS-1 are observed. The TS-1 catalyst can also promote the formation of oxiranes from various p-substituted allyloxybenzenes in good yields. The reaction mechanism is investigated through the reaction with other allyloxy compounds. The results, which are supported by DFT calculations, indicate that an active species of Ti peroxides formed from the reaction of TS-1 with H2O2 selectively oxidizes the allyloxybenzene to 2-(phenoxymethyl)oxirane.

A facile and efficient method for synthesis of β-iodocarboxylates from terminal epoxides

A facile and efficient method has been developed for synthesis of β-iodocarboxylates in the presences of Ph3P/I2. Starting from epoxides, a series of β-iodocarboxylate compounds can be directly obtained in toluene media with excellent yields. Moreover, the method was successfully applied for the late-stage modification of natural products, such as isosteviol and vincamine derivatives, achieving the corresponding β-iodocarboxylates in good yields.

Montmorillonite K10 catalyzed highly regioselective azidolysis of epoxides: A short and efficient synthesis of phenylglycine

A series of β‐hydroxyazides were effectively synthesized from the regioselective ring opening of epoxides by sodium azide using montmorillonite K10 as a novel heterogeneous catalyst in aqueous acetonitrile in good to excellent yields. The utility of this method has been demonstrated by achieving a short synthesis of phenylglycine in 33.5% overall yield.

Identification and validation of small molecule modulators of the NusB-NusE interaction

Formation of highly possessive antitermination complexes is crucial for the efficient transcription of stable RNA in all bacteria. A key step in the formation of these complexes is the protein-protein interaction (PPI) between N-utilisation substances (Nu

Synthesis of 2-(phenoxymethyl)oxirane derivatives through unexpected rearrangement of oxiran-2-ylmethyl benzenesulfonates

The synthesis of 2-(phenoxymethyl)oxirane derivatives from oxiran-2-ylmethyl benzenesulfonates was developed through a base promoted rearrangement. A new C-O bond was formed along with the unexpected cleavage of C-S bond via this process. This unusual reaction was characterized with mild reaction conditions, high efficiency, and excellent functional group tolerance. A plausible reaction mechanism was proposed on the basis of experimental results and control experiments.

An unusual (R)-selective epoxide hydrolase with high activity for facile preparation of enantiopure glycidyl ethers

A novel epoxide hydrolase (BMEH) with unusual (R)-enantioselectivity and very high activity was cloned from Bacillus megaterium ECU1001. Highest enantioselectivities (E>200) were achieved in the bioresolution of ortho-substituted phenyl glycidyl ethers and para-nitrostyrene oxide. Worthy of note is that the substrate structure remarkably affected the enantioselectivities of the enzyme, as a reversed (S)-enantiopreference was unexpectedly observed for the ortho-nitrophenyl glycidyl ether. As a proof-of-concept, five enantiopure epoxides (>99% ee) were obtained in high yields, and a gram-scale preparation of (S)-ortho-methylphenyl glycidyl ether was then successfully performed within a few hours, indicating that BMEH is an attractive biocatalyst for the efficient preparation of optically active epoxides. Copyright

Synthesis of aryloxyacetaldehydes and N-(aryloxyethyl)cyclohexanamine hydrochloroides

Oxidation of 2-(aryloxymethyl)oxiranes with periodic acid gave a series of aryloxyacetaldehydes which reacted with cyclohexylamine in THF, and subsequent reduction of Schiff bases thus obtained with sodium tetrahydridoborate resulted in the formation of the corresponding secondary amines which were isolated and characterized as hydrochlorides.

5-Oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase

The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof, wherein: W, A, Y, Z, R101 and R200 are described in the specification.

2,4-DIAMINO PYRIMIDINE COMPOUNDS HAVING ANTI-CELL PROLIFERATIVE ACTIVITY

A pyrimidine derivative of formula (I) wherein, for example, R1 is hydrogen, (1-6C)alkyl, (3-5C)alkenyl or (3-5C)alkynyl; Q1 and Q2 are independently selected from phenyl, naphthyl, indanyl and 1,2,3,4-tetrahydronaphthyl; and one or both of Q1 and Q2 bear