125232-25-9Relevant academic research and scientific papers
Fabrication and morphology control of the electrostatic self-assembled system containing porphyrin electrolytes and sulfonated fullerene derivatives
Wang, Ning,Zhang, Xiaona,Zheng, Wei,Ouyang, Dan,Yang, Renqiang
, p. 72 - 79 (2015)
A series of water-soluble porphyrin electrolytes with quaternary ammonium ions side chains (TEMZnPN and THMZnPN) and sulfonated fullerene derivatives were synthesised and characterised. The self-assembled system was fabricated through the electrostatic in
Mitochondrial-targeting curcumin derivative as well as preparation method and medical application thereof
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Paragraph 0074-0077; 0134-0137, (2021/07/21)
The invention relates to the field of natural medicines and medicinal chemistry, in particular to a mitochondria-targeting curcumin derivative. The invention also discloses a preparation method of the curcumin derivative and application of the curcumin de
Fabrication and morphology control of the electrostatic self-assembled system containing porphyrin electrolytes and sulfonated fullerene derivatives
Wang, Ning,Zhang, Xiaona,Zheng, Wei,Ouyang, Dan,Yang, Renqiang
, p. 72 - 79 (2015/04/14)
A series of water-soluble porphyrin electrolytes with quaternary ammonium ions side chains (TEMZnPN and THMZnPN) and sulfonated fullerene derivatives were synthesised and characterised. The self-assembled system was fabricated through the electrostatic in
New para-para stilbenophanes: Synthesis by mcmurry coupling, conformational analysis and inhibition of tubulin polymerisation
Alvarez, Raquel,Lopez, Vilmari,Mateo, Carmen,Medarde, Manuel,Pelaez, Rafael
experimental part, p. 3406 - 3419 (2011/05/02)
The synthesis of a new family of methoxy-substituted [2.7]- and [2.8]paracyclophanes linked by 3-oxapentamethylene-1,5-dioxy and hexamethylene-1,6-dioxy bridges has been carried out by using the McMurry methodology. Related indole compounds were also synthesised. Olefin-to-diol ratios depended on the bridge length, the structure of the aromatic ring and the reaction conditions. Macrocyclisation, the methoxy substituents and the presence of a rigid indole moiety restricted the conformational equilibria, as observed by NMR spectroscopy and according to theoretical calculations. The synthesised compounds display micromolar tubulin polymerisation inhibitory activity. The conformational implications on the tubulin polymerisation inhibitory activity derived from the macrocyclisation when compared with combretastatins, closely related stilbenes, are also discussed. Flip-flop: McMurry coupling of dialdehydes was successfully used to complete the synthesis of macrocyclic stilbene analogues of combretastatins in variable yields (an example of which is depicted). These molecules have several exchanging conformations, as studied by NMR spectroscopy and theoretical calculations, and are the first macrocyclic inhibitors of tubulin polymerisation of their class. Copyright
A cage compound derived from cyclotriveratrylene and diphenylglycoluril sub-units
Smeets, J. W. H.,Coolen, H. K. A. C.,Zwikker, J. W.,Nolte, R. J. M.
, p. 215 - 218 (2007/10/02)
To diphenylglycoluril (2), four aliphatic chains were attached, each with a vanillyl alcohol group at the end.In an acid-catalyzed reaction, three of the vanillyl alcohol groups cyclize to form a cyclotriveratrylene unit.The resulting compound (3) has a w
