125247-70-3

Basic information

• Product Name: 7-O-isopropyl fangchinoline
• Synonyms: 7-O-isopropyl fangchinoline
• CAS NO: 125247-70-3
• Molecular Formula: C40H46 N2 O6
• Molecular Weight: 650.8
• Mol File: 125247-70-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 724.1°Cat760mmHg
• Flash Point: 174.6°C
• Appearance: /
• Density: 1.152g/cm³
• Vapor Pressure: 8.09E-21mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 7-O-isopropyl fangchinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-O-isopropyl fangchinoline(125247-70-3)
• EPA Substance Registry System: 7-O-isopropyl fangchinoline(125247-70-3)

Safety Data

• Hazardous Substances Data: 125247-70-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C40H46N2O6/c1-24(2)46-39-37(45-7)22-28-15-17-42(4)32-19-26-10-13-33(43-5)35(20-26)47-29-11-8-25(9-12-29)18-31-30-23-36(48-40(39)38(28)32)34(44-6)21-27(30)14-16-41(31)3/h8-13,20-24,31-32H,14-19H2,1-7H3/t31-,32-/m0/s1

Upstream product

• 75-26-3 isopropyl bromide 
• 436-77-1 fangchinoline 

Relevant articles and documents

Reversal of P-glycoprotein-dependent resistance to vinblastine by newly synthesized bisbenzylisoquinoline alkaloids in mouse leukemia P388 cells

We examined the ability of partially synthesized new compounds from fangchinoline and tetrandrine to reverse P-glycoprotein (P-gp)-dependent multidrug resistance (MDR) in vitro and in vivo. All compound enhanced the in vitro cyctotoxic effect of vinblastin (VBL) at 0.1 μM as potent as 10 μM verapamil against the resistant cell line P388/ADR. The combination effect tended to be strong by substitution of bulky group, resulting 5,14-dibromotetrandrine (compound #9) showed the strongest effect. Compound #9 increased intracellular VBL accumulation in P388/ADR cells, much stronger than verapamil, as well as cytotoxic combined effect. This mechanism seems to inhibit the function of P-gp, but not the expression of P-gp. In combination with VBL, this compound also synergistically prolonged the life-span of P388/ADR-bearing mice. Bisbenzylisoquinoline alkaloids and their derivatives are possible to be good candidates as modifier of MDR in cancer chemotherapy.