1252616-03-7

Basic information

• Product Name: 8-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1,4-dioxa-spiro[4.5]decan-8-ol
• Synonyms: 8-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1,4-dioxa-spiro[4.5]decan-8-ol
• CAS NO: 1252616-03-7
• Molecular Weight: 364.557
• Mol File: 1252616-03-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 8-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1,4-dioxa-spiro[4.5]decan-8-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 8-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1,4-dioxa-spiro[4.5]decan-8-ol(1252616-03-7)
• EPA Substance Registry System: 8-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1,4-dioxa-spiro[4.5]decan-8-ol(1252616-03-7)

Safety Data

• Hazardous Substances Data: 1252616-03-7(Hazardous Substances Data)

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 67963-68-2 t-butyldimethylsilyl-4-bromophenol 

Downstream Products

• 105640-07-1 4-(4-hydroxyphenyl)cyclohexan-1-one 

Relevant articles and documents

Preparation method of 4-(4-hydroxyphenyl) cyclohexanone

The invention relates to the technical field of chemical synthesis, in particular to a preparation method of 4-(4-hydroxyphenyl) cyclohexanone. According to the preparation method, p-bromophenol is used as a raw material, a Grignard reagent is prepared through hydroxyl protection and Grignard reaction, then the prepared Grignard reagent is utilized to couple with 1,4-cyclohexanedione monoethyleneglycol ketal, then the product is dehydrated to obtain alkene, and double protecting groups are removed after hydrogenation to prepare a target product, namely, 4-(4-hydroxyphenyl) cyclohexanone. Thepreparation method of 4-(4-hydroxyphenyl) cyclohexanone, provided by the invention, has the advantages of reasonable process design, high yield and low production cost; the prepared 4-(4-hydroxyphenyl) cyclohexanone is a white solid, the HPLC content is more than 99.5%, the total yield of the product can reach 75-80%, and the raw materials are easy to obtain; and the method has simple operation and high safety, and realizes industrial production of 4-(4-hydroxyphenyl) cyclohexanone.