125272-41-5Relevant academic research and scientific papers
A simple Preparation of 5'-O-dimethoxytrityl Deoxyribonucleoside 3'-O-Phosphorbisdiethylamidites as Useful Intermediates in the Synthesis of Oligodeoxyribonucleotides and Their Phosphorodiethylamidate Analogs on a Solid Support
Yamana, Kazushige,Nishijima, Yoshitaka,Oka, Atsushi,Nakano, Hidehiko,Sangen, Osamu,et al.
, p. 4135 - 4140 (2007/10/02)
5'-O-Dimethoxytrityl deoxyribonucleoside 3'-O-phosphorbisdiethylamidites were prepared by the selective phosphitylation of 5'-O-dimethoxytrityl deoxyribonucleosides with tris(diethylamino)phosphine in the presence of amine and tetrazol as catalyst.The bisamidites activated by p-nitrophenyltetrazole can be coupled efficiently with 5'hydroxyl group of nucleoside on a solid support.Oligodeoxyribonucleotides were obtined in high yields.The phosphorodiethylamidate linkage was obtained by non-aqueous oxidation using tert-butyl hydroperoxyde of the phosphordiethylamidite formed after the coupling.
A CONVENIENT AND GENERAL APPROACH TO THE SYNTHESIS OF PROPERLY PROTECTED d-NUCLEOSIDE-3'-HYDROGENPHOSPHONATES VIA PHOSPHITE INTERMEDIATES
Marugg, J. E.,Tromp, M.,Kuyl-Yeheskiely, E.,Marel, G. A. van der,Boom, J. H. van
, p. 2661 - 2664 (2007/10/02)
Evidence will be presented to show that the monofunctional phosphitylating reagents bis(N,N-di-ethylamino)chlorophosphine and salicylchlorophosphine are very effective for the preparation of 5'-O,N-protected d-nucleoside-3'-hydrogenphosphonates.
