125288-36-0

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 125288-34-8 benzylideneacetophenone dimethyl acetal 

Downstream Products

• 130442-31-8 (Z)-4-Methoxy-2,4-diphenyl-2-butenenitrile 

Relevant academic research and scientific papers

Reactions of Acetals of α,β-Unsaturated Ketones with Silylated Nucleophiles as Trimethylsilyl Cyanide and Phenylthiotrimethylsilanes

A result of the reaction between phenylthiotrimethylsilane and (E)-chalcone dimethyl acetal let us to reinvestigate the structure of the isomerized products obtained from the reaction of acetals of (E)-chalcone derivatives with trimethyl cyanide recently

Efficient Activation of Acetals, Aldehydes, and Imines toward Silylated Nucleophiles by the Combined Use of Catalytic Amounts of 2 and TMS-CN under Almost Neutral Conditions

In the presence of catalytic amount of a transition metal compound such as 2, Co(acac)2, or NiCl2, trimethylsilyl cyanide smoothly reacts with acetals to form α-methoxy carbonitriles in good yields.In the coexistence of catalytic amounts of Rh

Efficient Method for the Preparation of (Z)-α-Alkoxy-β,γ-unsaturated Nitriles Starting from the corresponding Acetals of (E)-Chalcone Derivatives

In the presence of a catalytic amount of 2 or trityl perchlorate, trimethylsilyl cyanide smoothly reacts with (E)-chalcone dimethyl acetal to yield (Z)-2,4-diphenyl-2-methoxy-3-butenenitrile accompanying isomerization of double bond.

Efficient Activation of Acetals toward Nucleophiles by the Use of Transition Metal Salts. New Method for Cyanation of Acetals and Orthoester Derived from Aromatic and α,β-Unsaturated Carbonyl Compounds with Trimethylsilyl Cyanide under Neutral Condition

In the presence of a catalytic amount of transition metal salts (NiCl2, CoCl2, PdCl2, etc.), trimethylsilyl cyanide smoothly reacts with acetals or orthoester derived from aromatic and α,β-unsaturated carbonyl compounds to give the corresponding α-cyano d