125289-53-4Relevant academic research and scientific papers
Optimization of asymmetric hydrogenation of 3-phenyl-3-butenoic acid catalyzed by rhodium(I)-4,5-bis-2,2-dimethyldioxolane (DIOP)
Yamamoto, Keiji,Ikeda, Kiyoshi,Yin, Leong Kwai
, p. 319 - 332 (2007/10/02)
Enantioselective, homogeneous hydrogenation of 3-phenyl-3-butenoic acid (1) has extensively been examined in the presence of the rhodium(I)/4,5-bis-2,2-dimethyldioxolane (DIOP) catalyst systems.Optimization of the reaction conditions was undertaken mainly by controlling effects of added tertiary amines as well as solvent polarities on the enantio-selectivity of the product.The best asymmetric yield (85.1percent e.e.) was attained when the hydrogenation was carried out in the presence of triethylamine (5 molpercent) in 75percent aqueous methanol using a neutral rhodium-DIOP catalyst.
