1253107-42-4

Basic information

• Product Name: 9-Anthraceneacetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester
• Synonyms: 9-Anthraceneacetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester;2,5-Dioxopyrrolidin-1-yl 2-(Anthracen-9-yl)acetate
• CAS NO: 1253107-42-4
• Molecular Formula: C20H15NO4
• Molecular Weight: 333.3374
• Product Categories: Aromatics;Heterocycles
• Mol File: 1253107-42-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Chloroform, Ethyl Acetate
• CAS DataBase Reference: 9-Anthraceneacetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Anthraceneacetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester(1253107-42-4)
• EPA Substance Registry System: 9-Anthraceneacetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester(1253107-42-4)

Safety Data

• Hazardous Substances Data: 1253107-42-4(Hazardous Substances Data)

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 6624-23-3 9-anthrylacetic acid 
• 24463-19-2 anthracenylmethyl chloride 

Relevant articles and documents

Two-step labeling of endogenous enzymatic activities by Diels-Alder ligation

A ligation strategy based on the Diels-Alder [4+2] cycloaddition for the two-step activity-based labeling of endogenously expressed enzymes in complex biological samples has been developed. A panel of four diene-derivatized proteasome probes was synthesized, along with a dienophile-functionalized BODIPY(TMR) tag. These probes were applied in a Diels-Alder labeling procedure that enabled us to label active proteasome β-subunits selectively in cellular extracts and in living cells. We were also able to label the activity of cysteine proteases in cell extracts by utilizing a diene-derivatized cathepsin probe. Importantly, the Diels-Alder strategy described here is fully orthogonal with respect to the Staudinger-Bertozzi ligation, as demonstrated by the independent labeling of different proteolytic activities by the two methods in a single experiment.