125313-57-7Relevant academic research and scientific papers
A new one step synthesis of maleimides by condensation of glyoxylate esters with acetamides
Faul, Margaret M.,Winneroski, Leonard L.,Krumrich, Christine A.
, p. 1109 - 1112 (1999)
Bisphenyl, bisheteroaryl, indolylaryl and indolylcycloalkyl maleimides are prepared in one step and 67-99% yield by condensation of glyoxylate esters with acetamides using a 1.0 M solution of potassium tert-butoxide in THF. The mechanism of the reaction is discussed.
Synthesis of aryl- and heteroaryl[a]pyrrolo[3,4-c]carbazoles
Sanchez-Martinez, Concha,Faul, Margaret M.,Shih, Chuan,Sullivan, Kevin A.,Grutsch, John L.,Cooper, Jeremy T.,Kolis, Stanley P.
, p. 8008 - 8014 (2003)
Synthesis of aryl- and hetero[a]pyrrolo[3,4-c]carbazoles by photochemical oxidation and Heck cyclization are described. Photochemical oxidation of 2-naphthyl indolyl maleimide affords two different carbazole regioisomers, depending on the reaction conditi
Fluorescence and chemiluminescence properties of indolylmaleimides: Experimental and theoretical studies
Nakazono, Manabu,Jinguji, Ai,Nanbu, Shinkoh,Kuwano, Ryoichi,Zheng, Zilong,Saita, Kenichiro,Oshikawa, Yuji,Mikuni, Yuta,Murakami, Tatsuhiro,Zhao, Yi,Sasaki, Shigeki,Zaitsu, Kiyoshi
experimental part, p. 9783 - 9793 (2011/04/25)
Various indolylmaleimides (IMs) were synthesized, and their fluorescence (FL) and chemiluminescence (CL) were measured. The substitution at the 2-position of the indole ring and the 3- or 4-position of the maleimide moiety caused an obvious change in the
Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors
Peifer, Christian,Stoiber, Thomas,Unger, Eberhard,Totzke, Frank,Sch?chtele, Christoph,Marmé, Dieter,Brenk, Ruth,Klebe, Gerhard,Schollmeyer, Dieter,Dannhardt, Gerd
, p. 1271 - 1281 (2007/10/03)
The new analogue 2 of combretastatin A-4 was discovered to be an inhibitor of tubulin polymerization with an IC50 of 7.6 μM and reduced angiogenesis in the in vivo chick embryo model. Interestingly, in a series of 2,3-diarylmaleimides closely r
Aryl[a]pyrrolo[3,4-c]carbazoles as selective Cyclin D1-CDK4 inhibitors
Sanchez-Martinez, Concha,Shih, Chuan,Faul, Margaret M.,Zhu, Guoxin,Paal, Michael,Somoza, Carmen,Li, Tiechao,Kumrich, Christine A.,Winneroski, Leonard L.,Xun, Zhou,Brooks, Harold B.,Patel, Bharvin K. R.,Schultz, Richard M.,DeHahn, Tammy B.,Spencer, Charles D.,Watkins, Scott A.,Considine, Eileen,Dempsey, Jack A.,Ogg, Catherine A.,Campbell, Robert M.,Anderson, Bryan A.,Wagner, Jill
, p. 3835 - 3839 (2007/10/03)
The synthesis of new analogues of Arcyriaflavin A in which one indole ring is replaced by an aryl or heteroaryl ring is described. These new series of aryl[a]pyrrolo[3,4-c]carbazoles were evaluated as inhibitors of Cyclin D1-CDK4. A potent and selective D
Oxidative cyclisations with palladium acetate. A short synthesis of staurosporine aglycone
Harris,Hill,Keech,Malsher
, p. 8361 - 8364 (2007/10/02)
A palladium acetate mediated oxidative cyclisation has been used as the key step for the syntheses staurosporine aglycone and related analogues.
Substituted pyrroles
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, (2008/06/13)
Compounds of the formula STR1 wherein R1, R2, R3, R4, R5, R6, R7, X and Y have the signficance given in the description, are useful in the control or prevention of inflammatory, immunological, bronchopulmonary or cardiovascular disorders.
