3464-18-4

Basic information

• Product Name: 2,5-Pyrrolidinedione, 3-phenyl-
• CAS NO: 3464-18-4
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.187
• Mol File: 3464-18-4.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 2,5-Pyrrolidinedione, 3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Pyrrolidinedione, 3-phenyl-(3464-18-4)
• EPA Substance Registry System: 2,5-Pyrrolidinedione, 3-phenyl-(3464-18-4)

Safety Data

• Hazardous Substances Data: 3464-18-4(Hazardous Substances Data)

Usage

General Description

2,5-Pyrrolidinedione, 3-phenyl-, also known as phenytoin, is an organic compound commonly used as an anticonvulsant medication to treat various types of seizures. It works by stabilizing the electrical activity in the brain and preventing the excessive firing of neurons that can lead to seizures. Phenyltoin is also used to treat certain types of irregular heart rhythms and has been investigated for its potential neuroprotective and anti-inflammatory properties. However, it can have several side effects, including dizziness, drowsiness, and gastrointestinal disturbances, and should be used with caution in patients with liver or kidney disease. It is classified as a hydantoin derivative and has a chemical structure consisting of a pyrrolidine ring with a phenyl group attached to the third carbon atom.

Upstream product

• 635-51-8 2-phenylsuccinic acid 
• 22903-00-0 3-(methylthio)-4-phenyl-1H-pyrrole-2,5-dione 
• 49601-28-7 5-hydroxyimino-4-methylthio-3-phenyl-3-pyrrolin-2-one 
• 541-59-3 maleiimide 
• 71-43-2 benzene 
• 98-80-6 phenylboronic acid 
• 140-29-4 phenylacetonitrile 
• 201230-82-2 carbon monoxide 
• 536-74-3 phenylacetylene 
• 62-53-3 aniline 
• 1131-15-3 2-phenylsuccinic anhydride 
• 65-85-0 benzoic acid 
• 13706-68-8 (+-)-phenylsuccinonitrile 
• 79573-89-0 2-phenylmaleonitrile 

Downstream Products

• 1600513-95-8 2,5-dimethyl-3-phenylpyrrole-1-carboxylic acid methyl ester 
• 1600513-77-6 2,5-dioxo-3-phenyl-pyrrolidine-1-carboxylic acid methyl ester 
• 936-44-7 3-phenylpyrrolidine 
• 1239885-29-0 C₂₁H₂₂ClN₃O₂ 
• 1262047-57-3 C₂₂H₂₂F₃N₃O₂ 
• 1262047-56-2 C₂₁H₂₂FN₃O₂ 
• 19027-49-7 C₂₁H₂₂ClN₃O₂ 
• 1262047-58-4 C₂₂H₂₅N₃O₂ 
• 17330-67-5 C₂₁H₂₃N₃O₂ 
• 128562-22-1 rel-(1R,6S,7R,8aR)-7-acetoxy-6-(benzyloxymethyl)hexahydro-1-methyl-1-phenyl-3(2H)-indolizinone 
• 128562-22-1 rel-(1R,6S,7S,8aS)-7-acetoxy-6-(benzyloxymethyl)hexahydro-1-methyl-1-phenyl-3(2H)-indolizinone 
• 128562-22-1 rel-(1R,6R,7S,8aS)-7-acetoxy-6-(benzyloxymethyl)hexahydro-1-methyl-1-phenyl-3(2H)-indolizinone 
• 128562-18-5 3-benzyl-1-(2-(benzyloxymethyl)-3-butenyl)-5-ethoxy-3-phenyl-2-pyrrolidione 
• 128562-24-3 rel-(1R,6S,7S,8aS)-7-acetoxy-1-benzyl-6-(benzyloxymethyl)hexahydro-1-phenyl-3(2H)-indolizinone 

Relevant articles and documents

Stereochemical studies. XLV. A novel regiospecific ring opening of optically active 2 substituted 1 tosylaziridines

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Stereoselective One-Pot Synthesis of cis-1,2-Dicyanoalkenes from 1,1-Bis(benzenesulfonyl)alkenes and KCN

An efficient synthesis of cis-1,2-dicyanoalkenes by the reaction of 1,1-bis(benzenesulfonyl)alkenes with KCN was developed. This reaction was conducted in the presence of tetrabutylammonium bromide and NH4Cl/K3PO4 under phase-transfer conditions. A series of cis-1,2-dicyanoalkenes were obtained in good to high yields. Further transformation of the obtained product allows for access to imide and dicarboxylic acid compounds.

Synthetic derivatives of isoquinoline, dicarboxylic acid imides and thioimides as bioactive compounds

This study is a continuation of a research program aimed at identifying potent drugs against bacterial infections, in which a series of organic compounds: dicarboxylic acid imides and thioimides, isoquinoline derivatives and open chain compounds, were examined for antimicrobial properties against Staphylococcus aureus and Escherichia coli. In effect of this investigation, the most active compounds (35-40, 47) were selected for in vitro tests against fourteen clinically important pathogenic isolates, the methicillin resistant Staphylococcus aureus (MRSA) and several reference Gram-negative bacteria: Proteus vulgaris, Pseudomonas aeruginosa, Klebsiella pneumonia, Stenotrophomonas maltophilia, and Acinetobacter baumannii. The obtained data revealed that seven compounds (three dithioimides, 35, 39, 47, and four thioimides, 36-38, 40) exhibit effective antibacterial activity against the tested Staphylococcus aureus MSSA and MRSA strains. Among them, dicarboxylic acid thioimides 37 and 38 were proven to be the most active.