125313-97-5Relevant articles and documents
A practical method for the synthesis of indolylaryl- and bisindolylmaleimides
Roy, Sudipta,Roy, Sujata,Gribble, Gordon W.
, p. 4975 - 4977 (2006)
(Chemical Equation Presented) Indolylaryl and indolylheteroarylmaleimides, including bisindolylmaleimides, are easily prepared by the reaction of N-methylindole-3-glyoxylamide with methyl aryl acetates in the presence of potassium tert-butoxide in THF.
Indolylpyrrole derivatives and cell death inhibitors
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, (2008/06/13)
The invention provides a compound represented by the following formula (I) useful for inhibiting death of cells, the drug being expected as a preventive or a remedy for the progress of various diseases wherein cell death participates in progress and exace
Process for the preparation of 2-substituted and 2,3-disubstituted maleimides
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, (2008/06/13)
The invention relates to a process for the manufacture of substituted maleimides of the formula STR1 wherein R 1 is alkyl, aryl or heteroaryl and R 2 is hydrogen, alkyl, alkoxycarbonyl, aryl or heteroaryl, by reacting an activated glyoxylate of the formula STR2 wherein R 1 has the above significance and X is a leaving atom or group,with an imidate of the formula STR3 wherein R 2 has the above significance, R 3 is alkyl, aryl or trialkylsilyl and Y is oxygen or sulfur, in the presence of a base and, after treating the resulting reaction product obtained in which R 2 is hydrogen or alkyl with a strong base, hydrolyzing and dehydrating the resulting hydroxy-pyrrolinone of the formula STR4 wherein R 1, R 2, R 3 and Y have the above significance. The substituted maleimides of formula I are pharmacologically active, for example as protein kinase C inhibitors and which a useful, for example, in the treatment and prophylaxis of inflammatory, immunological, bronchopulmonary and cardiovascular disorders, or as antiproliferative agents useful, for example, in the treatment of immune diseases and allergic disorders.
