16382-39-1

Usage

Uses

Used in Pharmaceutical Industry:
2-(1-Methyl-1H-indol-3-yl)-2-oxoacetamide is used as an IDO inhibitor for its potential therapeutic applications in cancer treatment. It modulates the immune response and exhibits anti-inflammatory effects, which can be beneficial in managing cancer progression and the side effects of cancer therapies.
Used in Neuroprotection Research:
In the field of neurodegenerative diseases, 2-(1-Methyl-1H-indol-3-yl)-2-oxoacetamide is used as a research compound to explore its potential neuroprotective properties. Its role in neuroprotection is still under investigation, and further studies are required to understand its mechanisms of action and potential applications in treating neurodegenerative conditions.

Upstream product

• 5548-10-7 indole-3-glyoxylamide 
• 74-88-4 methyl iodide 
• 16382-38-0 1-methylindole-3-glyoxylyl chloride 
• 51584-17-9 1-methyl-1H-indole-3-acetonitrile 
• 19012-02-3 N-methyl-3-acetylindole 
• 703-80-0 3-acetylindole 
• 603-76-9 1-methylindole 

Downstream Products

• 125313-98-6 3-(4-methoxyphenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 
• 125313-97-5 3-(1-methyl-3-indolyl)-4-phenyl-1H-pyrrole-2,5-dione 

Relevant academic research and scientific papers

Copper(II)-Mediated Aerobic Oxidation of Benzylimidates: Synthesis of Primary α-Ketoamides

A simple and straightforward method for the synthesis of primary α-ketoamides has been discovered. The reaction represents the first example of benzylimidates directly converting to primary α-ketoamides by using sustainable molecular oxygen as an oxidant. This reaction proceeds in the presence of copper(II) salt via cleavage of benzylic C-H and C-O bonds of the benzylimidates with liberation of alcohols as the only byproduct. A wide substrate scope, operationally mild conditions, the use of single substrates, and a reaction scaled up to grams make this strategy very attractive and practical. Furthermore, mechanistic studies illustrate that the imidate group adjacent to the benzylic position plays crucial role in facilitating this chemical process.

Formamidine hydrochloride as an amino surrogate: I2-catalyzed oxidative amidation of aryl methyl ketones leading to free (N-H) α-ketoamides

A highly efficient molecular iodine catalyzed oxidative amidation of aryl methyl ketones with formamidine hydrochloride has been developed. This reaction represents a novel strategy for the synthesis of free (N-H) α-ketoamides. Based on the experimental r

A new synthesis of versatile indolyl-3-carbonylnitriles

Abstract Indolyl-3-carbonylnitriles are compounds with demonstrated utility as intermediates in organic chemistry. However, their synthesis remains a challenge, requiring the use of toxic sources of cyanide, and often proceeding in low yields. Accordingly, presented here is a new synthesis of these versatile reactants, via dehydration of easily accessible α-oxoacetamides in generally high yields under simple reaction conditions.

The first synthesis of [11C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3)

SB-216763 is a novel, potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor with an IC50 value of 34 nM. [11C]SB- 216763 (3-(2,4-dichlorophenyl)-4-(1-[11C]methyl-1H-indol-3-yl)-1H- pyrrole-2,5-dione), a new potential PET agent for imaging of GSK-3, was first designed and synthesized in 20-30% decay corrected radiochemical yield and 370-555 GBq/μmol specific activity at end of bombardment (EOB). The synthetic strategy was to prepare a carbon-11-labeled maleic anhydride intermediate followed by the conversion to maleimide.

A practical method for the synthesis of indolylaryl- and bisindolylmaleimides

(Chemical Equation Presented) Indolylaryl and indolylheteroarylmaleimides, including bisindolylmaleimides, are easily prepared by the reaction of N-methylindole-3-glyoxylamide with methyl aryl acetates in the presence of potassium tert-butoxide in THF.