125313-99-7 Usage
Uses
Used in Pharmaceutical Industry:
3-(4-Chlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione is used as a key intermediate in the synthesis of new drugs for various therapeutic areas. Its unique molecular structure allows for the development of compounds with novel pharmacological properties, contributing to the advancement of medicinal chemistry.
Used in Research Applications:
In the research field, 3-(4-Chlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione serves as a valuable research tool for studying biological processes. Its specific molecular structure enables researchers to investigate its interactions with biological targets, providing insights into the underlying mechanisms of action and potential applications in drug discovery.
Used in Drug Discovery:
3-(4-Chlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione is employed in drug discovery efforts to identify new lead compounds with potential therapeutic applications. Its unique chemical properties and interactions with biological targets make it a promising candidate for the development of innovative drugs to address unmet medical needs.
Used in Chemical Synthesis:
3-(4-Chlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione is utilized in chemical synthesis processes to create a variety of compounds with diverse applications. Its versatile molecular structure allows for the formation of new chemical entities, expanding the scope of synthetic chemistry and enabling the development of novel materials and compounds with specific properties.
Check Digit Verification of cas no
The CAS Registry Mumber 125313-99-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,3,1 and 3 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 125313-99:
(8*1)+(7*2)+(6*5)+(5*3)+(4*1)+(3*3)+(2*9)+(1*9)=107
107 % 10 = 7
So 125313-99-7 is a valid CAS Registry Number.
125313-99-7Relevant academic research and scientific papers
Synthesis and initial in vivo studies with [11C]SB-216763: The first radiolabeled brain penetrative inhibitor of GSK-3
Li, Lei,Shao, Xia,Cole, Erin L.,Ohnmacht, Stephan A.,Ferrari, Valentina,Hong, Young T.,Williamson, David J.,Fryer, Tim D.,Quesada, Carole A.,Sherman, Phillip,Riss, Patrick J.,Scott, Peter J. H.,Aigbirhio, Franklin I.
supporting information, p. 548 - 552 (2015/05/27)
Quantifying glycogen synthase kinase-3 (GSK-3) activity in vivo using positron emission tomography (PET) imaging is of interest because dysregulation of GSK-3 is implicated in numerous diseases and neurological disorders for which GSK-3 inhibitors are bei
Inhibitors of Protein Kinase C. 1. 2,3-Bisarylmaleimides
Davis, Peter D.,Hill, Christopher H.,Lawton, Geoffrey,Nixon, John S.,Wilkinson, Sandra E.,et al.
, p. 177 - 184 (2007/10/02)
The design and synthesis of a series of novel inhibitors of protein kinase C (PKC) is described.These 2,3-bisarylmaleimides were derived from the structural lead provided by the indolocarbazoles, staurosporine and K252a.Optimum activity required the imide NH, both carbonyl groups, and the olefinic bond of the maleimide ring. 2,3-Bisindolylmaleimides were the most active, and the potency of these was improved by a chloro substituent at the 5-position of one indole ring (compound 28, IC50 0.11 μM).In a series of (phenylindolyl)maleimides, nitro compound 74 was most active (IC50 0.67 μM).Naphthalene 19 and benzothiophene 21 showed greater than 100-fold selectivity for inhibition of PKC over the closely related cAMP-dependent protein kinase (PKA).
Substituted pyrroles
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, (2008/06/13)
Compounds of the formula STR1 wherein R1, R2, R3, R4, R5, R6, R7, X and Y have the signficance given in the description, are useful in the control or prevention of inflammatory, immunological, bronchopulmonary or cardiovascular disorders.
