1253180-99-2Relevant academic research and scientific papers
Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents
Csuk, Rene,Albert, Sabrina,Siewert, Bianka,Schwarz, Stefan
experimental part, p. 669 - 678 (2012/09/07)
Several new (E) stilbenes were synthesized by a combination of a Wittig olefination followed by Mizoroki-Heck coupling reactions. These compounds were screened for antitumor activity in a panel of 8 human cancer cell lines by a colorimetric SRB assay. Several of these compounds exhibit strong cytotoxicity. The most active compound of this series showed an average IC50 value of 0.03 μmol; it acts by apoptosis as shown by a dye-exclusion test, an extra acridine orange/ethidium bromide staining and DNA-laddering experiments.
Pd-catalyzed dearboxylative heck coupling with dioxygen as the terminal oxidant
Fu, Zhengjiang,Huang, Shijun,Su, Weiping,Hong, Maochun
supporting information; experimental part, p. 4992 - 4995 (2010/12/25)
Pd-catalyzed decarboxylative Heck coupling of aromatic carboxylic acids with various olefins is developed using O2 as the terminal oxidant. Enhancement of O2 pressure leads to improving reaction turnover in this transformation and allows significantly reducing catalyst loading for efficient conversion of electron-rich benzoic acids. A Pd catalyst supported by a carbene ligand enables using electron-deficient benzoic acids as coupling partners.
