1253182-42-1

Basic information

• Product Name: 2,6-dibromo-4-(pyrrolidin-1-yl)pyridine
• Synonyms: 2,6-dibromo-4-(pyrrolidin-1-yl)pyridine
• CAS NO: 1253182-42-1
• Molecular Weight: 306
• Mol File: 1253182-42-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,6-dibromo-4-(pyrrolidin-1-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dibromo-4-(pyrrolidin-1-yl)pyridine(1253182-42-1)
• EPA Substance Registry System: 2,6-dibromo-4-(pyrrolidin-1-yl)pyridine(1253182-42-1)

Safety Data

• Hazardous Substances Data: 1253182-42-1(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 175422-04-5 2,6-dibromo-4-nitropyridine 

Downstream Products

• 1408315-37-6 N,N',N-tris(p-anisyl)azacolix[3](2,6)(4-pyrrolidinopyridine) 
• 1408315-40-1 N,N',N-tris(p-anisyl)azacolix[3](2,6)(4-pyrrolidinopyridine) hydrogen bromide 
• 1408315-38-7 N,N-bis[2-(6-bromo-4-pyrrolidinopyridinyl)]-p-anisidine 
• 1516933-41-7 (4-pyrr-^MesPDI)CoCH₃ 
• 1255773-41-1 2,6-bis(p-tolylamino)-4-pyrrolidinopyridine 
• 1255773-39-7 N,N-bis[2-(6-bromo-4-pyrrolidinopyridyl)]-p-toluidine 
• 1609288-89-2 C₆₄H₆₈N₁₂O₄ 
• 1609288-75-6 C₁₆H₁₈BrN₃O 
• 1609288-73-4 C₁₆H₁₈BrN₃ 

Relevant articles and documents

Nitrogen heterocyclic compound, pharmaceutical composition containing nitrogen heterocyclic compound, and preparation method and application of nitrogen heterocyclic compound

Disclosed are a nitrogen heterocyclic compound represented by a formula (I), a pharmaceutical composition comprising the same, and a preparation method and use of the nitrogen heterocyclic compound, and in particular, relates to the use of the nitrogen heterocyclic compound for prevention or treatment of diseases or conditions associated with RET activity.

Complexes of click-derived bistriazolylpyridines: Remarkable electronic influence of remote substituents on thermodynamic stability as well as electronic and magnetic properties

2,6-Bis(1,2,3-triazol-4-yl)pyridine (btp) ligands with substitution patterns ranging from strongly electrondonating to strongly electron-accepting groups, readily prepared by means of Cu-catalyzed 1,3-dipolar cycloaddition (the "click" reaction), were investigated with regard to their complexation behavior, and the properties of the resulting transition-metal compounds were compared. Metal-btp complexes of 1:1 stoichiometry, that is, [Ru-(btp)Cl2(dmso)] and [Zn(btp)Br2], could be isolated and were crystallographically characterized: they display octahedral and trigonal-bipyramidal coordination geometries, respectively, and exhibit high aggregation tendencies due to efficient π-π stacking leading to low solubilities. Metal-btp complexes of 1:2 stoichiometry, that is, [Fe-(btp) 2]2+ and [Ru(btp)2]2+, could also be synthesized and their metal centers show the expected octahedral coordination spheres. The iron compounds exhibit quite a complex magnetic behavior in the solid state including spin crossover near room temperature, and hysteresis and locking into high-spin states on tempering at 400 K, depending on the substituents on the btp ligands. Cyclic voltammetry studies of [Ru(btp) 2]2+ reveal strong modulation of the oxidation potentials by more than 0.6 V and a clear linear correlation to the Hammett constant (σpara) of the substituent at the pyridine core. Isothermal titration calorimetry was used to measure the thermodynamics of the Fe II-btp complexation process and enabled accurate determination of the complexation enthalpies, which display a linear relationship with the σpara values for the terminal phenyl substituents. Detailed NMR spectroscopic studies finally revealed that in the case of FeII complexation, dynamics are rapid for all investigated btp derivatives in acetonitrile, while replacing FeII by RuII or changing the solvent to dichloromethane effectively slows down ligand exchange. The results nicely demonstrate the utility of substituent parameters, originally developed for linear free-energy relationships to explain reactivity in organic reactions, in coordination chemistry, and to illustrate the potential to customdesign btp ligands and complexes thereof with predictable properties. The fast equilibration of the [Fe-(btp)2]2+ complexes together with their tunable stability and interesting magnetic properties should enable the design of dynamic metallosupramolecular materials with advantageous properties.