1253291-12-1

Basic information

• Product Name: Methanone, [4-(difluoroMethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-
• Synonyms: Methanone, [4-(difluoroMethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-;GRN-529
• CAS NO: 1253291-12-1
• Molecular Formula: C₂₂H₁₅F₂N₃O₂
• Molecular Weight: 391.3702064
• EINECS: -0
• Mol File: 1253291-12-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methanone, [4-(difluoroMethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, [4-(difluoroMethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-(1253291-12-1)
• EPA Substance Registry System: Methanone, [4-(difluoroMethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-(1253291-12-1)

Safety Data

• Hazardous Substances Data: 1253291-12-1(Hazardous Substances Data)

Upstream product

• 1197357-98-4 4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)benzoic acid 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 1131614-23-7 4-difluoromethoxy-3-iodo-benzoic acid methyl ester 
• 605-38-9 dimethyl 2,3-pyridinedicarboxylate 
• 423169-40-8 2,3-bis(hydroxymethyl)pyridine hydrochloride 
• 45754-12-9 2,3-bis(chloromethyl)-pyridine 
• 1197357-97-3 methyl 4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)benzoate 
• 15126-06-4 methyl 3-iodo-4-hydroxybenzoate 

Relevant articles and documents

Difluoromethylation of Phenols and Thiophenols with the S-(Difluo-romethyl)sulfonium Salt: Reaction, Scope, and Mechanistic Study

A facile and practical approach for the difluoromethylation of phenols and thiophenols was described. Making use of the recently developed bench-stable S-(difluoromethyl)sulfonium salt as the difluorocarbene precursor, a wide variety of diversely functionalized phenols and thiophenols were readily converted to their corresponding aryl difluoromethyl ethers in good to excellent yields in the presence of lithium hydroxide. Chemoselectivity of various O,S-nucleophiles toward difluorocarbene was systematically studied, suggesting the reactivity order ArS- > RS-, ArO- > ROH > RO-, ArSH, ArOH, RSH.