423169-40-8

Basic information

• Product Name: 2,3-DihydroxyMethylpyridine hydrochloride
• Synonyms: [2-(hydroxymethyl)pyridin-3-yl]methanol;2,3-dihydroxymethylpyridine HCl;2,3-DihydroxyMethylpyridine hydrochloride;Pyridine-2,3-diyldiMethanol hydrochloride;2,3-Pyridinedimethanol hydrochloride;[3-(hydroxymethyl)pyridin-2-yl]methanol hydrochloride
• CAS NO: 423169-40-8
• Molecular Formula: C₇H₉NO₂*ClH
• Molecular Weight: 175.6128
• Mol File: 423169-40-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,3-DihydroxyMethylpyridine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DihydroxyMethylpyridine hydrochloride(423169-40-8)
• EPA Substance Registry System: 2,3-DihydroxyMethylpyridine hydrochloride(423169-40-8)

Safety Data

• Hazardous Substances Data: 423169-40-8(Hazardous Substances Data)

Usage

General Description

2,3-DihydroxyMethylpyridine hydrochloride is a chemical compound with the molecular formula C6H7NO2·HCl. It is commonly used as a synthetic intermediate and building block in the pharmaceutical industry, particularly in the production of drugs and medications. The compound contains a pyridine ring with hydroxymethyl and hydroxyl functional groups, and the hydrochloride salt form increases its stability and solubility in aqueous solutions. 2,3-DihydroxyMethylpyridine hydrochloride has potential applications in the development of therapies for various medical conditions, and its properties make it a versatile and valuable chemical in pharmaceutical research and development.

Upstream product

• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 605-38-9 dimethyl 2,3-pyridinedicarboxylate 

Downstream Products

• 45754-12-9 2,3-bis(chloromethyl)-pyridine 
• 147739-88-6 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine 
• 1253291-12-1 (4-difluoromethoxy-3-pyridin-2-ylethynyl-phenyl)-(5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-methanone 
• 27221-49-4 2,3-bis(chloromethyl)pyridine hydrochloride 

Relevant articles and documents

A robust process for an mGluR5 negative allosteric modulator: Difluoromethylation and sonogashira coupling on large scale

The development of the potent and selective mGluR5 negative allosteric modulator (NAM) 1 is described. Key features in the process, which has been implemented on a multikilogram scale, include a high-temperature difluoromethylation reaction, a Sonogashira coupling, and careful control of residual Pd and Cu in the final API. Due to the relative nonpolar nature of the intermediates, water-miscible solvents were employed in all four steps to allow for direct crystallizations upon reaction completion. In addition, several crystalline morphologies of the API were discovered, and the isolation of the desired form II will be discussed.

Reaction safety: A critical parameter in the development of a scaleable synthesis of 2,3-bis-chloromethylpyridine hydrochloride

This report describes the development of a scaleable process to prepare 2,3-bis(chloromethyl)pyridine hydrochloride, 2, that is safe, economical, and environmentally acceptable. On a small scale this material is prepared using thionyl chloride as the solv