423169-40-8

Usage

Uses

Used in Pharmaceutical Industry:
2,3-DihydroxyMethylpyridine hydrochloride is used as a synthetic intermediate for the development of various drugs and medications. Its unique structure and functional groups make it a valuable component in the synthesis of pharmaceutical compounds.
Used in Drug Synthesis:
2,3-DihydroxyMethylpyridine hydrochloride is used as a building block in the synthesis of pharmaceutical compounds. Its presence in the molecular structure can contribute to the desired properties and therapeutic effects of the final drug product.
Used in Research and Development:
2,3-DihydroxyMethylpyridine hydrochloride is used as a versatile chemical in pharmaceutical research and development. Its potential applications in the development of therapies for various medical conditions make it an important tool for scientists and researchers in the field.

Upstream product

• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 605-38-9 dimethyl 2,3-pyridinedicarboxylate 

Downstream Products

• 27221-49-4 2,3-bis(chloromethyl)pyridine hydrochloride 
• 45754-12-9 2,3-bis(chloromethyl)-pyridine 
• 147739-88-6 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine 
• 1253291-12-1 (4-difluoromethoxy-3-pyridin-2-ylethynyl-phenyl)-(5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-methanone 

Relevant academic research and scientific papers

A robust process for an mGluR5 negative allosteric modulator: Difluoromethylation and sonogashira coupling on large scale

The development of the potent and selective mGluR5 negative allosteric modulator (NAM) 1 is described. Key features in the process, which has been implemented on a multikilogram scale, include a high-temperature difluoromethylation reaction, a Sonogashira coupling, and careful control of residual Pd and Cu in the final API. Due to the relative nonpolar nature of the intermediates, water-miscible solvents were employed in all four steps to allow for direct crystallizations upon reaction completion. In addition, several crystalline morphologies of the API were discovered, and the isolation of the desired form II will be discussed.

2,3-DIHYDRO-1H-ISOINDOL-1-IMINE DERIVATIVES USEFUL AS THROMBIN PAR-1 RECEPTOR ANTAGONIST

The present invention is directed to novel 2,3-dihydro-1H-isoindol-1-imine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the thrombin PAR-1 receptor antagonists.

Reaction safety: A critical parameter in the development of a scaleable synthesis of 2,3-bis-chloromethylpyridine hydrochloride

This report describes the development of a scaleable process to prepare 2,3-bis(chloromethyl)pyridine hydrochloride, 2, that is safe, economical, and environmentally acceptable. On a small scale this material is prepared using thionyl chloride as the solv