1253376-64-5Relevant academic research and scientific papers
Synthesis of 1,3-Diaryl-2-methoxyindenes by hydriodic acid-catalyzed cyclization of Aryl[2-(1-aryl-2-methoxyvinyl)phenyl]methanols
Kobayashi, Kazuhiro,Shirai, Yuu,Nagaoka, Toshiyuki,Konishi, Hisatoshi
experimental part, p. 2866 - 2881 (2009/12/03)
An efficient two-step method for the synthesis of 1,3-diaryl-2- methoxyindenes from 1-(1-aryl-2-methoxyvinyl)-2-bromobenzenes has been developed. Thus, the reaction of 2-(1-aryl-2-methoxyvinyl)phenyllithiums, generated in situ by halogen-lithium exchange between 1-(1-aryl-2-methoxyvinyl)- 2-bromobenzenes and butyllithium, with aromatic aldehydes gives aryl[2-(1-aryl-2-methoxyvinyl)phenyl]methanols, which in turn are treated with a catalytic amount of concentrated hydriodic acid to afford the corresponding 1,3-diaryl-2-methoxyindenes in reasonable yields.
