1253376-70-3Relevant academic research and scientific papers
Synthesis of 3-substituted benzo[b]thiophenes via the reaction of α-substituted 2-lithio-β-methoxystyrenes with sulfur
Kobayashi, Kazuhiro,Nakai, Daisuke,Fukamachi, Shuhei,Konishi, Hisatoshi
, p. 1703 - 1709 (2011/04/15)
3-Substitued benzo[b]thiophenes were synthesized in reasonable overall yields from α-substituted 2-bromo-β-methoxystyrenes. Thus, the bromine-lithium exchange between these bromostyrenes with butyllithium in diethyl ether at 0 °C followed by reaction with sulfur afforded the corresponding a-substituted β-methoxy-2-sulfanylstyrenes. These were then treated with an equimolar amount of concentrated hydriodic acid in acetonitrile at room temperature to give the desired products. The Japan Institute of Heterocyclic Chemistry.
