1253444-75-5Relevant academic research and scientific papers
Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners
Kamal, Ahmed,Shetti, Rajesh V. C. R. N. C.,Azeeza, Shaik,Ahmed, S. Kaleem,Swapna,Reddy, A. Malla,Khan, Inshad Ali,Sharma, Sandeep,Abdullah, Sheikh Tasduq
, p. 4545 - 4553 (2010)
In an effort to discover new and effective chemotherapeutic agents from this laboratory for the treatment of tuberculosis, here in we describe the synthesis and biological evaluation of a series of novel benzothiadiazine 1,1-dioxide (BTD) based congeners by using rifampicin, streptomycin; ciprofloxacin and amphotericin as positive controls. Further, to understand structural requirements for exploring the structure activity relationship of BTDs, cytotoxicity and in vivo study of recently reported potent molecule 4 (MIC = 1 μg/mL) is also discussed.
