1253518-08-9Relevant academic research and scientific papers
An effcient protocol for accessing β-Amino dicarbonyl compounds through aza-Michael reaction
Meskini, Ihssan,Toupet, Loi?c,Daoudi, Maria,Kerbal, Abdelali,Bennani, Brahim,Dixneuf, Pierre H.,Chohan, Zahid H.,Leite, Ana Cristina Lima,Hadda, Taibi Ben
, p. 1129 - 1135 (2010)
β-Amino dicarbonyl compounds comprise a class of useful ligands on the coordination chemistry. In view of their importance, an effcient and facile method for the synthesis of β-amino dicarbonyl compounds has been developed, exploring the aza-Michael addition reactions in an aqueous medium. It was possible to achieve good to excellent yields, along with regioselectivity, the substituted diethyl 2-(phenylmethyl)malonates that were easily isolated without any chromatographic purifcation. The correct confguration of two of these β-amino dicarbonyl compounds were confrmed by X-ray crystallography. A complementary mechanism of this aza-Michael protocol is proposed to explain the results obtained.
Structure of a β-amino dicarbonyl compound: 2-[(4-chloro-phenyl)- pyrrolidin-1-yl-methyl]-malonic acid diethyl ester
Meskini, Ihssan,Toupet, Loic,Daoudi, Maria,Kerbal, Abdelali,Ben Hadda, Taibi
, p. 891 - 894 (2011)
The titled new functionalized ligand 2-[(4-chloro-phenyl)-pyrrolidin-1-yl- methyl]-malonic acid diethyl ester (4) is prepared in good yield through condensation of pyrazole and 3,5-dimethyl-pyrazole, respectively, with 2-arylidene-malonic acid diethyl est
