1253700-37-6

Basic information

• Product Name: C₁₆H₁₈O₄
• Synonyms: C₁₆H₁₈O₄
• CAS NO: 1253700-37-6
• Molecular Weight: 274.317
• Mol File: 1253700-37-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₈O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₈O₄(1253700-37-6)
• EPA Substance Registry System: C₁₆H₁₈O₄(1253700-37-6)

Safety Data

• Hazardous Substances Data: 1253700-37-6(Hazardous Substances Data)

Upstream product

• 590-14-7 1-bromo-1-propene 
• 617-52-7 Dimethyl itakonate 
• 100-52-7 benzaldehyde 

Relevant articles and documents

A cobalt-catalyzed multicomponent approach to novel 2,3-Di-and 2,2,3-trisubstituted 3-methoxycarbonyl-γ-butyrolactones

A one-pot, three-component synthesis of the title butyrolactones starting from aryl bromides, dimethyl itaconate, and either aldehydes or ketones is described. The cobalt-catalyzed domino process formally involves the in situ metalation of an aromatic bromide, conjugate addition onto dimethyl itaconate, an aldolization reaction with a carbonyl compound and a final cyclization into a five-membered lactone. This procedure is applied to the concise synthesis of a range of functionalized γ-butyrolactones with a methyl paraconate subunit.