1253891-13-2Relevant articles and documents
Saturation transfer difference NMR reveals functionally essential kinetic differences for a sugar-binding repressor protein
Perez-Victoria, Ignacio,Kemper, Sebastian,Patel, Mitul K.,Edwards, John M.,Errey, James C.,Primavesi, Lucia F.,Paul, Matthew J.,Claridge, Timothy D. W.,Davis, Benjamin G.
, p. 5862 - 5864 (2009)
The binding kinetics of disaccharides trehalose and trehalose-6-phosphate to repressor protein TreR have been determined using STD NMR and shed light on the contrasting biological roles of these two sugars.
Simple one-pot regioselective 6-O-phosphorylation of carbohydrates and trehalose desymmetrization
Abragam Joseph,Chang, Chun-Wei,Wang, Cheng-Chung
, p. 11497 - 11499 (2013/12/04)
Biologically essential carbohydrate 6-phosphates, especially trehalose 6-phosphate, can be synthesized easily in excellent overall yields in 2 steps involving minimum protecting group manipulations. We can cleave the diphenylphosphate group for further synthetic objectives.
ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor
Barry, Conor S.,Backus, Keriann M.,Barry, Clifton E.,Davis, Benjamin G.
supporting information; experimental part, p. 13232 - 13235 (2011/10/10)
Mycobacterium tuberculosis Antigen 85 enzymes are vital to the integrity of the highly impermeable cell envelope and are potential therapeutic targets. Kinetic analysis using a label-free assay revealed both mechanistic details and a substrate profile tha