42390-78-3Relevant articles and documents
Engineering the Mycomembrane of Live Mycobacteria with an Expanded Set of Trehalose Monomycolate Analogues
Fiolek, Taylor J.,Banahene, Nicholas,Kavunja, Herbert W.,Holmes, Nathan J.,Rylski, Adrian K.,Pohane, Amol Arunrao,Siegrist, M. Sloan,Swarts, Benjamin M.
, p. 1282 - 1291 (2019)
Mycobacteria and related organisms in the Corynebacterineae suborder are characterized by a distinctive outer membrane referred to as the mycomembrane. Biosynthesis of the mycomembrane occurs through an essential process called mycoloylation, which involv
Ahibo-Coffy et al.
, p. 185,186, 188, 193 (1978)
Trehalose-based neuroprotective autophagy inducers
Arosio, Daniela,Assoni, Giulia,Colombo, Eleonora,Frapporti, Giulia,Gornati, Davide,Perez-Carrion, Maria Dolores,Piccoli, Giovanni,Polito, Laura,Seneci, Pierfausto
supporting information, (2021/03/23)
A small set of trehalose-centered putative autophagy inducers was rationally designed and synthesized, with the aim to identify more potent and bioavailable autophagy inducers than free trehalose, and to acquire information about their molecular mechanism
Lipid length and iso-branching of trehalose diesters influences Mincle agonist activity
Khan, Ayesha,Kodar, Kristel,Timmer, Mattie S.M.,Stocker, Bridget L.
, p. 1269 - 1277 (2017/12/11)
We report on the efficient synthesis of linear trehalose diesters (TDEs) and iso-branched TDEs (maradolipids or iso-TDEs) and their ability to activate bone marrow-derived macrophages (BMDMs) as determined by cytokine (IL-1β IL-12, IL-6, IL-10) and chemokine (MIP-2) production. Both classes of TDEs were found to activate BMDMs in a Mincle-dependent manner, with longer-chain (≥C18) lipids leading to a robust inflammatory response. On the whole, the iso-branched TDEs led to greater cytokine production and a faster immune response when compared to their linear counterparts. Moreover, C12-TDE and iso-C12-TDE elicited the production of MIP-2 by BMDMs, thereby providing the first example of TDEs with a chain length of ≤ C12 leading to a Mincle-dependent immune response and one that is less inflammatory in nature.