1253969-55-9

Basic information

• Product Name: C₂₇H₂₄ClN₇O
• CAS NO: 1253969-55-9
• Molecular Weight: 497.987
• Mol File: 1253969-55-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₂₄ClN₇O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₂₄ClN₇O(1253969-55-9)
• EPA Substance Registry System: C₂₇H₂₄ClN₇O(1253969-55-9)

Safety Data

• Hazardous Substances Data: 1253969-55-9(Hazardous Substances Data)

Upstream product

• 557770-89-5 4-(3-phenylpropylamino)-7-(2-chloroethoxy)quinazoline 
• 16499-57-3 7-fluoro-3H-quinazolin-4-one 
• 446-32-2 4-fluoroanthranilic acid 
• 557770-90-8 4-chloro-7-(3-chloropropoxy)quinazoline 
• 1026194-04-6 N-(5-amino-2-methylphenyl)-5-(3-pyridyl)-2-pyrimidinamine 

Downstream Products

• 1253969-34-4 C₃₁H₃₂N₈O₂ 
• 1253969-35-5 C₃₂H₃₄N₈O 
• 1253969-36-6 C₃₁H₃₄N₈O 
• 1253969-37-7 C₃₁H₃₂N₈O 

Relevant articles and documents

Synthesis and Quantum Chemical Studies of New 4-aminoquinazoline Derivatives as Aurora A/B Kinase Inhibitors

Nine novel 4-aminoquinazoline derivatives were designed and synthesized. Biochemical and cellular analyses demonstrated that most of the derivatives exhibited a strong activity to inhibit Aurora A and B kinases and to suppress the proliferation of a panel of human tumor cell lines (U937, K562, A549, LoVo, and HT29). Quantum chemical studies were also carried out to determine the structural features of these compounds engaged in the inhibition of Aurora kinases.