125399-14-6Relevant articles and documents
α-Hydroxy Phosphinyl-Based Inhibitors of Human Renin
Patel, Dinesh V.,Rielly-Gauvin, Katherine,Ryono, Denis E.,Free, Charles A.,Rogers, W. Lynn,et al.
, p. 4557 - 4569 (2007/10/02)
The design and application of α-hydroxy phosphonates, a new class of transition state analogs, toward the discovery of novel and potent inhibitors of the aspartyl protease renin is described.Tripeptidic α-hydroxy diethyl phosphonate 3, the first example i